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Open AccessGold-catalyzed four-component multifunctionalization of alkynes
The alkyne unit is a versatile building block in organic synthesis and the development of selective multifunctionalization of alkynes is an important object of research in this field. Herein, we report an inte...
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Article
Photoinduced gold-catalyzed divergent dechloroalkylation of gem-dichloroalkanes
The use of alkyl chlorides as C(sp3)-hybridized electrophiles for the construction of C(sp3)–C(sp3) bonds represents one of the most challenging issues in organic synthesis, associated with their low reduction po...
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Article
Open AccessHighly selective single and multiple deuteration of unactivated C(sp3)-H bonds
Selective deuteration of unactivated C(sp3)-H bonds is a highly attractive but challenging subject of research in pharmaceutical chemistry, material science and synthetic chemistry. Reported herein is a practical...
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Article
Photoinduced manganese-catalysed hydrofluorocarbofunctionalization of alkenes
The selective hydrofluorocarbofunctionalization of alkenes is an important synthetic strategy for efficiently constructing fluorine-containing compounds. However, existing methods often require expensive fluor...
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Article
Open AccessDecarboxylative tandem C-N coupling with nitroarenes via SH2 mechanism
Aromatic tertiary amines are one of the most important classes of organic compounds in organic chemistry and drug discovery. It is difficult to efficiently construct tertiary amines from primary amines via cla...
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Article
Open AccessHighly selective synthesis of all-carbon tetrasubstituted alkenes by deoxygenative alkenylation of carboxylic acids
The synthesis of all-carbon tetrasubstituted olefins under mild reaction conditions is challenging because of the inevitable issues including significant steric hindrance and the uncontrolled Z/E stereoselectivit...
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Article
Dinuclear gold-catalyzed C-H bond functionalization of cyclopropenes
We report an unprecedented C–H bond functionalization of cyclopropenes enabled by dinuclear gold catalysis. Highly selective C–H allylation, alkynylation and halogenation of cyclopropenes with organic halides ...
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Article
Open AccessSite-specific Umpolung amidation of carboxylic acids via triplet synergistic catalysis
Development of catalytic amide bond-forming methods is important because they could potentially address the existing limitations of classical methods using superstoichiometric activating reagents. In this pape...
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Article
Manganese-catalysed divergent silylation of alkenes
Transition-metal-catalysed, redox-neutral dehydrosilylation of alkenes is a long-standing challenge in organic synthesis, with current methods suffering from low selectivity and narrow scope. In this study, we...
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Article
Open AccessUpgrading ketone synthesis direct from carboxylic acids and organohalides
The ketone functional group has a unique reactivity in organic chemistry and is associated with a number of useful reactions. Catalytic methods for ketone synthesis are continually being developed. Here, we re...
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Article
A review of enantioselective dual transition metal/photoredox catalysis
Transition metal catalysis is one of the most important tools to construct carbon-carbon and carbon-heteroatom bonds in modern organic synthesis. Visible-light photoredox catalysis has recently drawn considera...
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Article
Open AccessLate-stage trifluoromethylthiolation of benzylic C-H bonds
The benzylic positions in drugs are sites that readily react with cytochrome P450 oxidases via single-electron oxidation. New synthetic methodologies to incorporate a fluoroalkyl group at the benzylic site are...
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Article
Open AccessA general deoxygenation approach for synthesis of ketones from aromatic carboxylic acids and alkenes
The construction of an aryl ketone structural unit by means of catalytic carbon–carbon coupling reactions represents the state-of-the-art in organic chemistry. Herein we achieved the direct deoxygenative keton...
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Book
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Chapter
Functionalization of C(sp3)–H Bond by Visible-Light Photoredox Catalysis
Solar energy is a unique and renewable resource in nature. Visible-light-induced organic reactions are featured as energy saving and environmentally benign. It becomes one ideal protocol for chemists to deal w...
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Chapter
Transition Metal-Catalyzed, Directing Group-Assisted C(sp3)–H Bond Functionalization
Highly regioselective C(sp3)–H bond functionalization is a very important and attractive research topic as organic compounds usually contain several different kinds of C–H bonds (sp, sp2, and sp3). The introducti...
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Chapter
Recent Advances in Non-directed C(sp3)–H Bond Functionalization
Selective functionalization of one specific C(sp3)–H bond in a complex molecule without the assistance of a directing group represents the state of the art in organic synthesis and will be a dynamic topic in futu...
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Article
Isoquinoline-catalyzed addition of 2-bromo-1-aryl-1-ethanone to dialkyl azodicarboxylate: synthesis of trialkyl 2-[(1E)-N-(alkoxycarbonyl)-2-aryl-2-oxoethanehydrazonoyl]hydrazine-1,1,2-tricarboxylate
A catalytic method for the synthesis of a class of hydrazine derivatives is reported. The described method provides convenient access to compounds which are anticipated to show biological activities. The salie...
