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Article
Open AccessAbnormalities in intron retention characterize patients with systemic lupus erythematosus
Regulation of intron retention (IR), a form of alternative splicing, is a newly recognized checkpoint in gene expression. Since there are numerous abnormalities in gene expression in the prototypic autoimmune ...
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Article
Open AccessTcf1 and Lef1 provide constant supervision to mature CD8+ T cell identity and function by organizing genomic architecture
T cell identity is established during thymic development, but how it is maintained in the periphery remains unknown. Here we show that ablating Tcf1 and Lef1 transcription factors in mature CD8+ T cells aberrantl...
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Article
Open AccessEzh2 programs TFH differentiation by integrating phosphorylation-dependent activation of Bcl6 and polycomb-dependent repression of p19Arf
Ezh2 is an histone methyltransferase (HMT) that catalyzes H3K27me3 and functions in TH1, TH2, and Treg cells primarily via HMT activity. Here we show that Ezh2 ablation impairs T follicular helper (TFH) cell diff...
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Article
Open AccessPredicting CTCF-mediated chromatin interactions by integrating genomic and epigenomic features
The CCCTC-binding zinc-finger protein (CTCF)-mediated network of long-range chromatin interactions is important for genome organization and function. Although this network has been considered largely invariant...
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Article
The transcription factor Runx3 guards cytotoxic CD8+ effector T cells against deviation towards follicular helper T cell lineage
Xue and colleagues show that Runx3−/− CD8+ T effector cells aberrantly upregulate genes characteristic of TFH cell lineage and exhibit impaired induction of cytotoxic molecules.
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Article
Tcf1 and Lef1 transcription factors establish CD8+ T cell identity through intrinsic HDAC activity
Xue and colleagues show that the transcription factors Tcf1 and Lef1 suppress CD4+ T lineage genes in CD8+ T cells through intrinsic histone deacetylase (HDAC) activity.
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Article
LEF-1 and TCF-1 orchestrate TFH differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6
Follicular helper T cells (TFH cells) are specialized effector CD4+ T cells that help B cells develop germinal centers and memory. Crotty and colleagues show that the transcription factors LEF-1 and TCF-1 are req...
