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Showing 1-20 of 20 results

  1. Padsevonil

    in Reactions Weekly
    Article 24 June 2023

  2. Development of SV2A Ligands for Epilepsy Treatment: A Review of Levetiracetam, Brivaracetam, and Padsevonil

    Epilepsy is a common neurological disorder that is primarily treated with antiseizure medications (ASMs). Although dozens of ASMs are available in...

    Peng-Peng Wu, Bi-Rong Cao, ... Zhao-Bing Gao in Neuroscience Bulletin
    Article 28 October 2023

  3. Clinical Bridging Studies and Modeling Approach for Implementation of a Patient Centric Sampling Technique in Padsevonil Clinical Development

    Volumetric absorptive microsampling (VAMS) techniques have gained popularity these last years as innovative tool for collection of blood...

    Hester Kramer, Ceyhun Bicer, ... Hugues Chanteux in The AAPS Journal
    Article Open access 16 November 2023

  4. On the Development of New Drugs for the Treatment of Drug-Resistant Epilepsy: An Update on Different Approaches to Different Hypotheses

    Despite the continuous expansion of the available pharmacological options for the treatment of epilepsies and remarkable advances in understanding...
    Alan Talevi in Pharmacoresistance in Epilepsy
    Chapter 2023

  5. Novel Mechanism, Drug Target and Therapy in Epilepsy

    Cenglin Xu, Yi Wang, Zhong Chen in Neuroscience Bulletin
    Article 24 April 2024

  6. Polypharmacology in Clinical Applications: Neurological Polypharmacology

    Neurological disorders include diverse subgroups, including neuromuscular diseases, genetic and metabolic disorders, developmental delay, traumatic...
    Zhiguo Wang, Baofeng Yang in Polypharmacology
    Chapter 2022

  7. Presynaptic antiseizure medications - basic mechanisms and clues for their rational combinations

    Among clinically highly efficient antiseizure medications (ASMs) there are modifiers of the presynaptic release machinery. Of them, levetiracetam and...

    Ewa K. Czapińska-Ciepiela, Jarogniew Łuszczki, ... Władysław Lasoń in Pharmacological Reports
    Article Open access 22 May 2024

  8. Assessment of cerebral drug occupancy in humans using a single PET-scan: A [11C]UCB-J PET study

    Purpose

    Here, we evaluate a PET displacement model with a Single-step and Numerical solution in healthy individuals using the synaptic vesicle...

    Maja R. Marstrand-Joergensen, Gjertrud L. Laurell, ... Lars H. Pinborg in European Journal of Nuclear Medicine and Molecular Imaging
    Article Open access 17 May 2024

  9. Antiepileptic Drugs

    Arne Reimers in Encyclopedia of Molecular Pharmacology
    Reference work entry 2021

  10. Protocol for 6 Hz Corneal Stimulation in Rodents for Refractory Seizures

    The 6-hertz (6 Hz) model is an effective tool to screen drugs for psychomotor seizures and/or treatment-resistant focal seizures. It is known to...
    Razia Khanam, Divya Vohora in Experimental and Translational Methods to Screen Drugs Effective Against Seizures and Epilepsy
    Protocol 2021

  11. Glutamate and Epilepsy: An Insight from Temporal Lobe Epilepsy

    The normal physiology of neurons is achieved through a delicate balance between excitatory and inhibitory synapses. Any disruption of such intricate...
    Alberto E. Musto in Glutamate and Neuropsychiatric Disorders
    Chapter 2022

  12. D-galactose Supplementation for the Treatment of Mild Malformation of Cortical Development with Oligodendroglial Hyperplasia in Epilepsy (MOGHE): A Pilot Trial of Precision Medicine After Epilepsy Surgery

    MOGHE is defined as mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy. Approximately half of the patients with...

    Ángel Aledo-Serrano, Adrián Valls-Carbó, ... Antonio Gil-Nagel in Neurotherapeutics
    Article 06 June 2023

  13. Antiepileptic Drugs

    Arne Reimers in Encyclopedia of Molecular Pharmacology
    Living reference work entry 2020

  14. Structures of synaptic vesicle protein 2A and 2B bound to anticonvulsants

    Epilepsy is a common neurological disorder characterized by abnormal activity of neuronal networks, leading to seizures. The racetam class of...

    Anshumali Mittal, Matthew F. Martin, ... Jonathan A. Coleman in Nature Structural & Molecular Biology
    Article 19 June 2024

  15. The Pharmacology and Clinical Efficacy of Antiseizure Medications: From Bromide Salts to Cenobamate and Beyond

    Epilepsy is one of the most common and disabling chronic neurological disorders. Antiseizure medications (ASMs), previously referred to as...

    Wolfgang Löscher, Pavel Klein in CNS Drugs
    Article Open access 18 June 2021

  17. Validation of Parametric Methods for [11C]UCB-J PET Imaging Using Subcortical White Matter as Reference Tissue

    Purpose

    The aim of this study was to evaluate different non-invasive methods for generating (R)-1-((3-([ 11 C]methyl)pyridin-4-yl)methyl)-4-(3,4,5-trifl...

    Nathalie Mertens, Ralph Paul Maguire, ... Michel Koole in Molecular Imaging and Biology
    Article 17 June 2019

  18. Quantifying SV2A density and drug occupancy in the human brain using [11C]UCB-J PET imaging and subcortical white matter as reference tissue

    Purpose

    A [ 11 C]UCB-J blocking study was performed in healthy volunteers to validate simplified, non-invasive measures for quantifying presynaptic...

    Michel Koole, June van Aalst, ... Koen Van Laere in European Journal of Nuclear Medicine and Molecular Imaging
    Article 18 August 2018
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