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Boric Acid Affects the Expression of DNA Double-Strand Break Repair Factors in A549 Cells and A549 Cancer Stem Cells: An In Vitro Study
DNA double-strand break (DSB) repair genes interact with tumor stemness- and resistance-associated processes in cancer stem cells (CSCs). Therefore,...
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Anticarcinogenic Effects of Gold Nanoparticles and Metformin Against MCF-7 and A549 Cells
Metformin is commonly prescribed to people with diabetes. Metformin has been shown in previous studies to be able to prevent the growth of cancer...
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TonEBP/NFAT5 expression is associated with cisplatin resistance and migration in macrophage-induced A549 cells
BackgroundMacrophages promote angiogenesis, metastasis, and drug resistance in several cancers. Similarly, TonEBP/NFAT5 induces metastasis in renal...
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A novel lncRNA-hidden polypeptide regulates malignant phenotypes and pemetrexed sensitivity in A549 pulmonary adenocarcinoma cells
The advance of high-throughput sequencing enhances the discovery of short ORFs embedded in long non-coding RNAs (lncRNAs). Here, we uncovered the...
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Synthesis, characterization, anticancer efficacy evaluation of ruthenium(II) and iridium(III) polypyridyl complexes toward A549 cells
A new ligand DFIP (2-(dibenzo[b,d]furan-3-yl)-1 H -imidazo[4,5-f][1,10]phenanthroline) and its two complexes iridium(III) [Ir(ppy) 2 (DFIP)](PF 6 )...
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Lysosome-targeted ruthenium(II) complex encapsulated with pluronic® F-127 induces oncosis in A549 cells
Transition metal complexes with characteristics of unique packaging in nanoparticles and remarkable cancer cell cytotoxicity have emerged as...
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Investigating the Effects of Temporin-Rb, an Antimicrobial Peptide, on Cell Viability and Pro-inflammatory Gene Expression in A549 Cells
This study investigates the effects of Temporin-Rb, an antimicrobial peptide, on A549 cells’ viability and pro-inflammatory gene expression. The MTT...
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Angelica acutiloba Kitagawa flower induces A549 cell pyroptosis via the NF-κB/NLRP3 pathway for anti-lung cancer effects
Angelica acutiloba Kitagawa, a traditional medicinal herb of the Umbelliferae family, has been demonstrated to have anticancer activity. In this...
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Antimicrobial and antitumor properties of anuran peptide temporin-SHf induce apoptosis in A549 lung cancer cells
Temporin-SHf is a linear, ultra-short, hydrophobic, α-helix, and phe-rich cationic antimicrobial peptide. The antitumor activities and mechanism of...
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Response of PRIMPOL-Knockout Human Lung Adenocarcinoma A549 Cells to Genotoxic Stress
AbstractHuman DNA primase/polymerase PrimPol synthesizes DNA primers de novo after replication fork stalling at the sites of DNA damage, thus...
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Synthesis and In vitro Antiproliferative Activity of 5-Halogen-6-nitrobenzo[c][1,2,5]selenadiazoles on A549 Cells
AbstractSelenadiazoles are of a broad spectrum of promising anticancer agents. However, excessive synthetic steps, larger molecular size and erratic...
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Silencing TAB182 inhibits cell EMT, migration and invasion by downregulating EGFR in A549 NSCLC cells
BackgroundTAB182 is overexpressed in cancerous tissues and correlated with poor overall survival in lung cancer patients. Mechanistically, TAB182...
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Transcriptomic analysis of glucosidase II beta subunit (GluIIß) knockout A549 cells reveals its roles in regulation of cell adhesion molecules (CAMs) and anti-tumor immunity
Glucosidase II beta subunit (GluIIß), encoded from PRKCSH , is a subunit of the glucosidase II enzyme responsible for quality control of N-linked...
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Morphological modification of silver nanoparticles against multi-drug resistant gram–negative bacteria and cytotoxicity effect in A549 lung cancer cells through in vitro approaches
In the present study, the individual cultures of Proteus mirabilis ( P. mirabilis ) and Klebsiella pneumoniae ( K. pneumoniae ) were treated with...
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Transcriptome-wide 5-methylcytosine modification profiling of long non-coding RNAs in A549 cells infected with H1N1 influenza A virus
BackgroundIn recent years, accumulating evidences have revealed that influenza A virus (IAV) infections induce significant differential expression of...
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Phenolic Contents, Antioxidant Activities, LCMS Profiles of Mespilus germanica Leaf Extract and Effects on mRNA Transcription Levels of Apoptotic, Autophagic, and Necrotic Genes in MCF7 and A549 Cancer Cell Lines
Cancer, defined by the continuous, uncontrollable proliferation of cells in the human body, is a disease with a rapidly increasing incidence and...
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Mitochondrial oxidative phosphorylation became functional under aglycemic hypoxia conditions in A549 cells
BackgroundNormal cells produce energy (ATP) through mitochondrial oxidative phosphorylation in the presence of oxygen. However, many of the cancer...
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8-Hydroxyquinoline a natural chelating agent from Streptomyces spp. inhibits A549 lung cancer cell lines via BCL2/STAT3 regulating pathways
Biomolecules from Streptomyces spp. are emerging sources of natural drugs and have been focused on over the decade. The discovery of bioactive...
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Investigation the effects of bee venom and H-dental-derived mesenchymal stem cells on non-small cell lung cancer cells (A549)
BackgroundLung cancer, one of the most common oncological diseases worldwide, continues to be the leading cause of cancer-related deaths. The...
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Anticancer Potential and Cytotoxic Activity of NN-32, a Snake Venom Peptide, Against A549, Lung Cancer Cell Line
Lung cancer is the prime cause of death after breast cancer among non-infectious diseases and is highly prevalent across the world. Several...
