Search
Search Results
-
Medicinal Polypharmacology in the Clinic – Translating the Polypharmacolome into Therapeutic Benefit
Drugs with multiple targets, often annotated as ‘unselective’, ‘promiscuous’, ‘multitarget’, or ‘polypharmacological’, are widely considered in both...
-
Basics of Polypharmacology
Polypharmacology is frequently referred to the design or use of pharmaceutical agents that act on multiple molecular targets or multiple signaling...
-
Strategies of Polypharmacology
In Chap. 1 , we have learned that the modern pharmacological therapy of human disease and new drug discovery are...
-
Polypharmacology Principles and Methodologies
There is a growing interest in unmet needs for the development of a new discipline in drug discovery and in university education on polypharmacology....
-
Polypharmacology and Natural Products
Natural products (NPs) play an important role in drug discovery. No less than 50% of the Food and Drug Administration (FDA)-approved drugs were NPs...
-
Polypharmacology in Clinical Applications: Metabolic Disease Polypharmacology
Metabolic diseases consisting of different groups of disorders are becoming increasingly prevalent and have a major impact on public health...
-
Polypharmacology: New Paradigms in Drug Development
Polypharmacology is the term coined for the interaction of drug molecules with multiple targets and is responsible for the side effects and...
-
Polypharmacology and Polypharmacokinetics
Polypharmacokinetics is a new concept in pharmacology. Polypharmacokinetics to polypharmacology is like pharmacokinetics to pharmacology. While...
-
Polypharmacology in Clinical Applications—Anticancer Polypharmacology
Polypharmacology is not only a theoretical discipline but also an experimental and application discipline. The ultimate goal of Polypharmacology is...
-
Polypharmacology in Clinical Applications: Respiratory Polypharmacology
The respiratory system is an open system that allows us to breathe, bring oxygen into our bodies (called inspiration or inhalation), and send carbon...
-
Polypharmacology in Clinical Applications: Cardiovascular Polypharmacology
Cardiovascular disease (CVD) is a class of disorders of the heart and blood vessels and the leading cause of death...
-
Polypharmacology in Clinical Applications: Neurological Polypharmacology
Neurological disorders include diverse subgroups, including neuromuscular diseases, genetic and metabolic disorders, developmental delay, traumatic...
-
Polypharmacology in Clinical Applications: Anti-infection Polypharmacology
Infectious diseases have for centuries ranked with wars and famine as major challenges to human progress and survival. They remain among the leading...
-
Polypharmacology in Predicting Drug Toxicity: Drug Promiscuity
Drug promiscuity refers to multitarget activity of a drug and can elicit two distinct or opposing actions: adverse side effects and improved...
-
Polypharmacology in Clinical Applications: Gastrointestinal Polypharmacology
The digestive system comprises the gastrointestinal track (GI track) and accessory organs/glands. Recent research discoveries prove that in addition...
-
Polypharmacology in Clinical Applications—Anti-inflammation Polypharmacology
Inflammation, a vital defense mechanism for health, is defined as the immune system’s response to harmful stimuli such as pathogens, damaged cells,...
-
Polypharmacology in Clinical Applications: Renal Polypharmacology
The urinary system, also known as the renal system or urinary tract, consists of the kidneys ,...
-
Polypharmacology in Drug Design and Discovery—Basis for Rational Design of Multitarget Drugs
Chapter 3 through Chap. 11 introduces the current status of clinical...
-
Steroidal lactones from Withania somnifera effectively target Beta, Gamma, Delta and Omicron variants of SARS-CoV-2 and reveal a decreased susceptibility to viral infection and perpetuation: a polypharmacology approach
Prevention from disease is presently the cornerstone of the fight against COVID-19. With the rapid emergence of novel SARS-CoV-2 variants, there is...
-
Polypharmacology in Old Drug Rediscovery: Drug Repurposing
The concept of drug repurposing has been introduced in this chapter (Sect. 13.8) as a new strategy for MTD drug discovery based on “promising...