Search
Search Results
-
Development of SV2A Ligands for Epilepsy Treatment: A Review of Levetiracetam, Brivaracetam, and Padsevonil
Epilepsy is a common neurological disorder that is primarily treated with antiseizure medications (ASMs). Although dozens of ASMs are available in...
-
Clinical Bridging Studies and Modeling Approach for Implementation of a Patient Centric Sampling Technique in Padsevonil Clinical Development
Volumetric absorptive microsampling (VAMS) techniques have gained popularity these last years as innovative tool for collection of blood...
-
On the Development of New Drugs for the Treatment of Drug-Resistant Epilepsy: An Update on Different Approaches to Different Hypotheses
Despite the continuous expansion of the available pharmacological options for the treatment of epilepsies and remarkable advances in understanding...
-
Polypharmacology in Clinical Applications: Neurological Polypharmacology
Neurological disorders include diverse subgroups, including neuromuscular diseases, genetic and metabolic disorders, developmental delay, traumatic...
-
-
Protocol for 6 Hz Corneal Stimulation in Rodents for Refractory Seizures
The 6-hertz (6 Hz) model is an effective tool to screen drugs for psychomotor seizures and/or treatment-resistant focal seizures. It is known to...
-
Glutamate and Epilepsy: An Insight from Temporal Lobe Epilepsy
The normal physiology of neurons is achieved through a delicate balance between excitatory and inhibitory synapses. Any disruption of such intricate...
-
D-galactose Supplementation for the Treatment of Mild Malformation of Cortical Development with Oligodendroglial Hyperplasia in Epilepsy (MOGHE): A Pilot Trial of Precision Medicine After Epilepsy Surgery
MOGHE is defined as mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy. Approximately half of the patients with...
-
-
