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Article
Open AccessAnnexin A2 combined with TTK accelerates esophageal cancer progression via the Akt/mTOR signaling pathway
Annexin A2 (ANXA2) is a widely reported oncogene. However, the mechanism of ANXA2 in esophageal cancer is not fully understood. In this study, we provided evidence that ANXA2 promotes the progression of esopha...
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Article
Celecoxib attenuates hindlimb unloading-induced muscle atrophy via suppressing inflammation, oxidative stress and ER stress by inhibiting STAT3
Improving inflammation may serve as useful therapeutic interventions for the hindlimb unloading-induced disuse muscle atrophy. Celecoxib is a selective non-steroidal anti-inflammatory drug. We aimed to determi...
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Article
Identification and validation of cuproptosis-related genes for diagnosis and therapy in nonalcoholic fatty liver disease
In recent years, nonalcoholic fatty liver disease (NAFLD) has become a more serious public health issue worldwide. This study strived to investigate the molecular mechanism of pathogenesis of NAFLD and explore...
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Article
Open AccessMagnetically driven capsules with multimodal response and multifunctionality for biomedical applications
Untethered capsules hold clinical potential for the diagnosis and treatment of gastrointestinal diseases. Although considerable progress has been achieved recently in this field, the constraints imposed by the...
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Article
Open AccessGWAS-identified hyperuricemia-associated IGF1R variant rs6598541 has a limited role in urate mediated inflammation in human mononuclear cells
Gout is a common autoinflammatory joint diseases characterized by deposition of monosodium urate (MSU) crystals which trigger an innate immune response mediated by inflammatory cytokines. IGF1R is one of the loci...
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Chapter and Conference Paper
DT-MUSA: Dual Transfer Driven Multi-source Domain Adaptation for WEEE Reverse Logistics Return Prediction
Reverse logistics (RL) return prediction for Waste Electrical and Electronic Equipment (WEEE) has gained attention due to its potential to improve operational efficiency in the recycling industry. However, in ...
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Article
A multi-constraint transfer approach with additional auxiliary domains for IoT intrusion detection under unbalanced samples distribution
The Internet of Things (IoT) refers to a vast and interconnected network comprising smart objects with comprehensive capabilities. Unfortunately, the vulnerabilities of IoT device awareness layer nodes are vul...
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Article
Transcriptome sequencing promotes insights on the molecular mechanism of SKP-SC-EVs mitigating denervation-induced muscle atrophy
Complex pathophysiological changes accompany denervation-induced skeletal muscle atrophy, but no effective treatment strategies exist. Our previous study indicated that extracellular vesicles derived from skin...
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Article
Open AccessSRPX2 promotes cancer cell proliferation and migration of papillary thyroid cancer
Thyroid cancer is the endocrine tumor with the highest incidence at present. It originates from the thyroid follicular epithelium or follicular paraepithelial cells. There is an increasing incidence of thyroid...
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Article
Open AccessPeripheral T Cell Populations are Differentially Affected in Familial Mediterranean Fever, Chronic Granulomatous Disease, and Gout
Both innate errors of immunity, such as familial Mediterranean fever (FMF) and chronic granulomatous disease (CGD), and the common inflammatory disease gout are characterized by episodes of sterile inflammator...
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Article
Open AccessACVRL1 drives resistance to multitarget tyrosine kinase inhibitors in colorectal cancer by promoting USP15-mediated GPX2 stabilization
Multitarget tyrosine kinase inhibitors (mTKIs) such as Regorafenib and Sorafenib have already been approved for the treatment of many solid tumours. However, the efficacy of mTKIs in colorectal cancer (CRC) is...
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Article
Open AccessInteraction between neutrophil extracellular traps and cardiomyocytes contributes to atrial fibrillation progression
Atrial fibrillation (AF) is a frequent arrhythmia associated with cardiovascular morbidity and mortality. Neutrophil extracellular traps (NETs) are DNA fragments with cytoplasm proteins released from neutrophi...
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Article
Open AccessMitochondrial dysfunction: roles in skeletal muscle atrophy
Mitochondria play important roles in maintaining cellular homeostasis and skeletal muscle health, and damage to mitochondria can lead to a series of pathophysiological changes. Mitochondrial dysfunction can le...
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Article
Distributed adaptive nearest neighbor classifier: algorithm and theory
When data is of an extraordinarily large size or physically stored in different locations, the distributed nearest neighbor (NN) classifier is an attractive tool for classification. We propose a novel distribu...
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Article
Open AccessComparison of machine learning models and CEUS LI-RADS in differentiation of hepatic carcinoma and liver metastases in patients at risk of both hepatitis and extrahepatic malignancy
CEUS LI-RADS (Contrast Enhanced Ultrasound Liver Imaging Reporting and Data System) has good diagnostic efficacy for differentiating hepatic carcinoma (HCC) from solid malignant tumors. However, it can be prob...
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Article
LDoS attack traffic detection based on feature optimization extraction and DPSA-WGAN
Low-rate Denial of Service (LDoS) attacks cause severe destructiveness to network security. Moreover, they are more difficult to detect because they are more hidden and lack distinguishing features. Consequent...
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Article
Open AccessSevere lymphopenia as a prognostic factor in rectal cancer patients receiving adjuvant chemoradiotherapy: a retrospective study
The relationship between total lymphocyte counts (TLCs) and survival is not well documented in rectal cancer. This study aimed to investigate the association between TLCs and disease-free survival (DFS) and id...
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Article
Comparative assessment of modified bentonites as retardation barrier: adsorption performance and characterization
Modified bentonites for the anti-seepage system have been attracting global attention. At the same time, the performances of modified bentonite containing retardation barrier exposed to organic–heavy metal pol...
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Article
Experimental study of the environmental and geotechnical properties of landfills under long-term leachate effects: macro–microscopic tests on in situ clays
Clay structures are widely used as impermeable barriers to landfill pollution, although waste can degrade for more than 30 years, no studies concerning the long-term service performance of clay layers under le...
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Article
A phosphorescent probe for in vivo imaging in the second near-infrared window
In the second near-infrared spectral window (NIR-II; with wavelengths of 1,000–1,700 nm), in vivo fluorescence imaging can take advantage of reduced tissue autofluorescence and lower light absorption and scatt...
