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Article
Open AccessLPA1 antagonist-derived LNPs deliver A20 mRNA and promote anti-fibrotic activities
Activated fibroblasts are major mediators of pulmonary fibrosis. Fibroblasts are generally found in the connective tissue but upon activation can generate excess extracellular matrix (ECM) in the lung intersti...
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Article
Open AccessClinical application of transcranial neuroendoscopy combined with supraorbital keyhole approach in minimally invasive surgery of the anterior skull base
To explore the techniques, safety, and feasibility of minimally invasive neurosurgery through the supraorbital eyebrow arch keyhole approach by neuroendoscopy. Retrospective analysis of clinical data of patien...
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Article
Synthesis of bio-based phosphorus-nitrogen hybrid cellulose nanocrystal flame retardant for improving of fire safety of epoxy resin
Bio-based materials as flame retardants meet the requirements of green strategy and sustainable development. Here nitrogen and phosphorus-modified bio-based cellulose nanocrystal composite (NPCNCs) were design...
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Article
Open AccessImpact of baseline cardiovascular risk on the outcomes of intensive blood pressure intervention: a post hoc analysis of the China rural hypertension control project
The 2018/2023 ESC/ESH Guidelines underlined a gap how baseline cardiovascular disease (CVD) risk predicted blood pressure (BP) lowering benefits. Further, 2017 ACC/AHA Guideline and 2021 WHO Guideline recommen...
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Article
Long and short-term characteristics of motion sickness: a test track investigation in a passenger car
With the development of autonomous cars, the incidence of motion sickness has increased. Current studies on the characteristics of motion sickness have primarily focused on its long-term characteristics while ...
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Article
Open AccessMETTL1-mediated tRNA m7G methylation and translational dysfunction restricts breast cancer tumorigenesis by fueling cell cycle blockade
RNA modifications of transfer RNAs (tRNAs) are critical for tRNA function. Growing evidence has revealed that tRNA modifications are related to various disease processes, including malignant tumors. However, t...
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Article
Effects of fuel and driving conditions on particle number emissions of China-VI gasoline vehicles: based on corrections to test results
The increasing number of vehicles are emitting a large amount of particles into the atmosphere, causing serious harm to the ecological environment and human health. This study conducted the Worldwide Harmonize...
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Article
Vector field path following for a micro flap**-wing robot
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Article
Open AccessU3 snoRNA inter-regulates with DDX21 in the perichromosomal region to control mitosis
U3 snoRNA is essential for ribosome biogenesis during interphase. Upon mitotic onset, the nucleolus disassembles and U3 snoRNA relocates to the perichromosomal region (PR) to be considered as a chromosome pass...
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Article
Open AccessRisk Factors of Chemotherapy-Induced Thrombocytopenia After Oxaliplatin-Containing Chemotherapy for Gastrointestinal Malignancies
Thrombocytopenia is among the most common chemotherapy-related hematologic toxicities. We aim to determine the predictors of oxaliplatin chemotherapy-induced thrombocytopenia in patients with gastrointestinal ...
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Article
Automated bone age assessment from knee joint by integrating deep learning and MRI-based radiomics
Bone age assessment (BAA) is a crucial task in clinical, forensic, and athletic fields. Since traditional age estimation methods are suffered from potential radiation damage, this study aimed to develop and ev...
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Article
TRIM38 Induced in Respiratory Syncytial Virus-infected Cells Downregulates Type I Interferon Expression by Competing with TRIM25 to Bind RIG-I
Innate immune response is the first line of defense for the host against virus invasion. One important response is the synthesis and secretion of type I interferon (IFN-I) in the virus-infected host cells. Her...
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Article
Constructing core-shell carbon fiber/polypyrrole/CoFe2O4 nanocomposite with optimized conductive loss and polarization loss toward efficient electromagnetic absorption
The inadequate impedance matching and weak attenuation capability for incident electromagnetic waves exhibited by carbon fibers (CF) are critical factors limiting their application served as absorbing material...
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Article
Open AccessCombined metagenomics and metabolomic analysis of microbial community structure and metabolic function in continuous soybean crop** soils of Songnen Plain, China
Continuous crop** has a negative effect on soybean yield. In this study, a positioning experiment was conducted starting in 2015, with three treatments: maize–soybean rotation (SMR), 2-year maize, 2-year soy...
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Article
Open AccessDo domestic budgerigars perceive predation risk?
Predation risk may affect the foraging behavior of birds. However, there has been little research on the ability of domestic birds to perceive predation risk and thus adjust their feeding behavior. In this stu...
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Article
Correction: A Joint Caching and Offloading Strategy Using Reinforcement Learning for Multi-access Edge Computing Users
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Article
Open AccessDysregulated lipid metabolism is associated with kidney allograft fibrosis
Interstitial fibrosis and tubular atrophy (IF/TA), a histologic feature of kidney allograft destruction, is linked to decreased allograft survival. The role of lipid metabolism is well-acknowledged in the area...
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Article
Anchoring Carbon Nanotubes onto Polyimide-Derived Vertical Carbon as Supporter of Paraffin for Thermal Interface Materials with High Thermal Conductivity
Phase-change materials (PCMs) used as thermal interface materials suffer from the problems of low thermal conductivity and leakage during phase-change processes. Here, a carbon supporter with a vertical hierar...
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Article
Open AccessLNP-RNA-engineered adipose stem cells for accelerated diabetic wound healing
Adipose stem cells (ASCs) have attracted considerable attention as potential therapeutic agents due to their ability to promote tissue regeneration. However, their limited tissue repair capability has posed a ...
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Article
A Joint Caching and Offloading Strategy Using Reinforcement Learning for Multi-access Edge Computing Users
The increasing adoption of UHD video applications in connected car mobile terminals is placing significant demands on the real-time processing capabilities of in-vehicle devices. Previous studies have proposed...
