-
Article
Open AccessHistone H3 binding to the PHD1 domain of histone demethylase KDM5A enables active site remodeling
Histone demethylase KDM5A removes methyl marks from lysine 4 of histone H3 and is often overexpressed in cancer. The in vitro demethylase activity of KDM5A is allosterically enhanced by binding of its product,...
-
Article
Erratum: Full antagonism of the estrogen receptor without a prototypical ligand side chain
Nat. Chem. Biol. 13, 111–118 (2017); published online 21 November 2016; corrected after print 17 March 2017 In the version of this article initially published, some of the chemical compounds were incorrectly n...
-
Article
Correction: Corrigendum: Full antagonism of the estrogen receptor without a prototypical ligand side chain
Nat. Chem. Biol. 13, 111–118 (2017); published online 21 November 2016; corrected after print 17 March 2017 In the version of this article initially published, Figure 1 was missing the ring designation letters...
-
Article
Open AccessMolecular assembly of rhodopsin with G protein-coupled receptor kinases
G protein-coupled receptor kinases (GRKs) play pivotal roles in desensitizing GPCR signaling but little is known about how GRKs recognize and phosphorylate GPCRs due to the technical difficulties in detecting ...
-
Article
Full antagonism of the estrogen receptor without a prototypical ligand side chain
A sulfonamide series lacking the prototypical side chain behave as full antagonists or inverse agonists of estrogen receptor (ERα) signaling in a graded fashion dependent on coactivator recruitment and helix-1...
-
Article
Time Window Expansion for HDX Analysis of an Intrinsically Disordered Protein
Application of typical HDX methods to examine intrinsically disordered proteins (IDP), proteins that are natively unstructured and highly dynamic at physiological pH, is limited because of the rapid exchange o...
-
Article
HDX Workbench: Software for the Analysis of H/D Exchange MS Data
Hydrogen/deuterium exchange mass spectrometry (HDX-MS) is an established method for the interrogation of protein conformation and dynamics. While the data analysis challenge of HDX-MS has been addressed by a n...
-
Article
Genetic and Functional Diversity among Fluorescent Pseudomonads Isolated from the Rhizosphere of Banana
Fluorescent pseudomonads from banana rhizospheric soil were isolated and screened for the production of enzymes and hormones such as phosphatase, indole-3-acetic acid (IAA), 1-aminocyclopropane-1-carboxylate (...
