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Article
Open AccessA deep dive into burn-mediated ARDS severity assessment: a retrospective study on hematological markers
Acute Respiratory Distress Syndrome (ARDS) is a critical form of Acute Lung Injury (ALI), challenging clinical diagnosis and severity assessment. This study evaluates the potential utility of various hematolog...
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Article
Open AccessBig data insights into the diagnostic values of CBC parameters for sepsis and septic shock in burn patients: a retrospective study
Sepsis and septic shock are prevalent and life-threatening complications in burn patients. Despite their severity, existing diagnostic methods are limited. This study aims to evaluate the efficacy of Complete ...
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Article
Open AccessPioneering predictions of AKI and AKIN severity in burn patients: a comprehensive CBC approach
This study aims to evaluate the utility of complete blood count (CBC) markers, in conjunction with the acute kidney injury network (AKIN) criteria, for the early detection, severity assessment, and prediction ...
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Article
Open AccessTracking longitudinal biomarkers in burn patients with sepsis and acute kidney injury: an unsupervised clustering approach
Sepsis is a grave medical disorder characterized by a systemic inflammatory response to infection. Furthermore, it is a leading cause of morbidity and mortality, especially in hospitalized patients. Acute kidn...
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Article
Open AccessEvaluating clinical heterogeneity and predicting mortality in severely burned patients through unsupervised clustering and latent class analysis
Burn injuries often result in a high level of clinical heterogeneity and poor prognosis in patients with severe burns. Clustering algorithms, which are unsupervised methods that can identify groups with simila...
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Article
Open AccessThe Hippo pathway effector YAP inhibits HIF2 signaling and ccRCC tumor growth
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Article
Open AccessYAP inhibits ERα and ER+ breast cancer growth by disrupting a TEAD-ERα signaling axis
Hippo signaling restricts tissue growth by inhibiting the transcriptional effector YAP. Here we uncover a role of Hippo signaling and a tumor suppressor function of YAP in estrogen receptor positive (ER+) breast ...
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Protocol
Characterization of Smoothened Phosphorylation and Activation
The GPCR-family protein Smoothened (Smo) is an obligatory signal transducer of the Hedgehog (Hh) signaling pathway. Binding of Hh to its receptor Patched (Ptc) alleviates Ptc-mediated inhibition of Smo, allowi...
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Article
Open AccessTime-varying discrimination accuracy of longitudinal biomarkers for the prediction of mortality compared to assessment at fixed time point in severe burns patients
The progression of biomarkers over time is considered an indicator of disease progression and helps in the early detection of disease, thereby reducing disease-related mortality. Their ability to predict outco...
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Article
Open AccessTrajectories of longitudinal biomarkers for mortality in severely burned patients
This study aimed to investigate the differences in the trajectory of blood biomarkers routinely assessed through forward- and backward-looking approaches among burn patients. This cohort study included patient...
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Article
Open AccessA population-based epidemiology of Wilson’s disease in South Korea between 2010 and 2016
Very few population-based studies have examined the epidemiology of Wilson’s disease (WD). We investigated the epidemiology of WD using the National Health Insurance Service (NHIS) database in South Korea. We ...
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Article
Clinical Outcome of Cryopreserved Acellular Dermal Matrix for Full-Thickness Burns
This study aimed at identifying properties of cryopreserved acellular dermal matrix (CPADM) and evaluating its effectiveness in the treatment of burn patients. The prospective study included 50 patients who re...
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Article
A nationwide population-based study of common bile duct stone recurrence after endoscopic stone removal in Korea
There is no consensus whether patients who underwent endoscopic common bile duct (CBD) stone removal should be followed up periodically and whether patients with gallbladder (GB) stones should undergo cholecys...
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Article
Open AccessRegulation of Yki/Yap subcellular localization and Hpo signaling by a nuclear kinase PRP4K
Hippo (Hpo) signaling pathway controls tissue growth by regulating the subcellular localization of Yorkie (Yki)/Yap via a cytoplasmic kinase cassette containing an upstream kinase Hpo/MST1/2 and a downstream k...
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Article
Open AccessOverlap** functions of the MAP4K family kinases Hppy and Msn in Hippo signaling
The Hippo (Hpo) tumor suppressor pathway is an evolutionarily conserved signaling pathway that controls tissue growth and organ size in species ranging from Drosophila to human, and its malfunction has been impli...
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Article
Open AccessInhibition of Pseudomonas aeruginosa with a recombinant RNA-based viral vector expressing human β-defensin 4
Harassed with extensive epithelial burn wounds, patients can be affected by complications, such as infection, hypovolemic shock, hypothermia, and respiratory failure. Immediate first aid and followed supportiv...
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Article
Open AccessAssessment of biochemical markers in the early post-burn period for predicting acute kidney injury and mortality in patients with major burn injury: comparison of serum creatinine, serum cystatin-C, plasma and urine neutrophil gelatinase-associated lipocalin
The reported mortality rates range from 28% to 100% in burn patients who develop acute kidney injury (AKI) and from 50% to 100% among such patients treated with renal replacement therapy. Recently, the serum c...
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Chapter and Conference Paper
A Hardware Implementation of Word-Parallel Bit-Serial Polynomial Basis Multiplier
In this paper, a hardware implementation of MSB-first word-parallel bit-serial multiplier with shorter delay time than other existing multipliers in finite field is presented. The proposed multiplier operates ...
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Article
Interferon regulatory factor-1 (IRF-1) is a mediator for interferon-γ induced attenuation of telomerase activity and human telomerase reverse transcriptase (hTERT) expression
Constitutive activation of the telomerase is a key step in the development of human cancers. Interferon-γ (IFN-γ) signaling induces growth arrest in many tumors through multiple regulatory mechanisms. In this stu...
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Article
Correction: Overexpression of the thymosin beta-10 gene in human ovarian cancer cells disrupts F-actin stress fiber and leads to apoptosis
