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Article
Nanotechnology in tissue engineering and regenerative medicine
Nanotechnology has advanced to unparalleled heights in biomaterials science. With the clear advantage of utilizing nanotechnology based systems compared to macroscale systems, such as targeted drug delivery, t...
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Article
Open AccessStromal Hedgehog pathway activation by IHH suppresses lung adenocarcinoma growth and metastasis by limiting reactive oxygen species
Activation of the Hedgehog (Hh) signaling pathway by mutations within its components drives the growth of several cancers. However, the role of Hh pathway activation in lung cancers has been controversial. Her...
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Article
Open AccessMacrophage hypoxia signaling regulates cardiac fibrosis via Oncostatin M
The fibrogenic response in tissue-resident fibroblasts is determined by the balance between activation and repression signals from the tissue microenvironment. While the molecular pathways by which transformin...
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Article
Open AccessThe distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition
Adenocarcinoma (ADC) and squamous cell carcinoma (SqCC) are the two predominant subtypes of non-small cell lung cancer (NSCLC) and are distinct in their histological, molecular and clinical presentation. Howev...
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Article
18F-Fluorodeoxyglucose uptake on positron emission tomography/computed tomography is associated with metastasis and epithelial-mesenchymal transition in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is the fifth leading cause of cancer mortality worldwide. Several studies have investigated the relationship between 18F-fluorodeoxyglucose (18F-FDG) uptake on positron emission tom...
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Reference Work Entry In depth
Warburg Effect
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Article
Open AccessNQO1 inhibits proteasome-mediated degradation of HIF-1α
Overexpression of NQO1 is associated with poor prognosis in human cancers including breast, colon, cervix, lung and pancreas. Yet, the molecular mechanisms underlying the pro-tumorigenic capacities of NQO1 hav...
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Article
Open AccessHIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity
In severely hypoxic condition, HIF-1α-mediated induction of Pdk1 was found to regulate glucose oxidation by preventing the entry of pyruvate into the tricarboxylic cycle. Monocyte-derived macrophages, however, en...
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Living Reference Work Entry In depth
Warburg Effect
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Article
GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression
Despite advances in our understanding of breast cancer, patients with metastatic disease have poor prognoses. GATA3 is a transcription factor that specifies and maintains mammary luminal epithelial cell fate, ...
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Reference Work Entry In depth
Warburg Effect
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Reference Work Entry In depth
Warburg Effect
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Article
The interplay between MYC and HIF in cancer
This Perspective considers the differences between the hypoxia-inducible factor (HIF)–MYC transcriptional network that operates under normal homeostatic conditions and the network that operates in a tumorigeni...
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Article
Effects of hypoxia on tumor metabolism
Rapidly growing tumors invariably contain hypoxic regions. Adaptive response to hypoxia through angiogenesis, enhanced glucose metabolism and diminished but optimized mitochondrial respiration confers survival...
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Chapter and Conference Paper
Towards the Optimal Design of an RFID-Based Positioning System for the Ubiquitous Computing Environment
Positioning technology is a core component of the ubiquitous computing environment. Radio Frequency IDentificaiton (RFID) is recognized as a powerful means of replacing not only barcodes for product identifica...
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Article
Open AccessPrimary and secondary transcriptional effects in the develo** human Down syndrome brain and heart
Down syndrome, caused by trisomic chromosome 21, is the leading genetic cause of mental retardation. Recent studies demonstrated that dosage-dependent increases in chromosome 21 gene expression occur in trisom...
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Article
Interferon regulatory factor-1 (IRF-1) is a mediator for interferon-γ induced attenuation of telomerase activity and human telomerase reverse transcriptase (hTERT) expression
Constitutive activation of the telomerase is a key step in the development of human cancers. Interferon-γ (IFN-γ) signaling induces growth arrest in many tumors through multiple regulatory mechanisms. In this stu...
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Article
Correction: Overexpression of the thymosin beta-10 gene in human ovarian cancer cells disrupts F-actin stress fiber and leads to apoptosis
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Article
Overexpression of the thymosin β-10 gene in human ovarian cancer cells disrupts F-actin stress fiber and leads to apoptosis
To understand the molecular changes during ovarian cancer development, we profiled differentially expressed genes in five paired normal and cancerous ovarian tissues. Among the genes that showed differential e...
