6 Result(s)

Article

RBCK1 is an endogenous inhibitor for triple negative breast cancer via hippo/YAP axis

Triple negative breast cancer (TNBC) is one of the most lethal breast cancer subtypes. Due to a lack of effective therapeutic targets, chemotherapy is still the main medical treatment for TNBC patients. Thus, ...

Zhongbo Li, Peng Su, Yinlu Ding, Honglei Gao… in Cell Communication and Signaling (2022)

Article

The Hippo pathway effector YAP inhibits HIF2 signaling and ccRCC tumor growth

Xu Li, Yong Suk Cho, Jian Zhu, Shu Zhuo, ** Jiang in Cell Discovery (2022)

Article

YAP inhibits ERα and ER⁺ breast cancer growth by disrupting a TEAD-ERα signaling axis

Hippo signaling restricts tissue growth by inhibiting the transcriptional effector YAP. Here we uncover a role of Hippo signaling and a tumor suppressor function of YAP in estrogen receptor positive (ER⁺) breast ...

Xu Li, Shu Zhuo, Ting Zhuang, Yong Suk Cho, Guo** Wu, Yuchen Liu… in Nature Communications (2022)

Article

Regulation of P53 signaling in breast cancer by the E3 ubiquitin ligase RNF187

The tumor suppressor P53 plays critical role in preventing cancer. P53 is rarely mutated and remains functional in luminal-type breast cancer(1). According to current knowledge, wild-type P53 function is tight...

**n Li, Zhiguo Niu, Chen Sun, Shu Zhuo, Huijie Yang, **ao Yang… in Cell Death & Disease (2022)

Article

Discovery of Novel Inhibitors and Fluorescent Probe Targeting NAMPT

Nicotinamide phosphoribosyltransferase (NAMPT) is a promising antitumor target. Novel NAMPT inhibitors with diverse chemotypes are highly desirable for development of antitumor agents. Using high throughput sc...

**a Wang, Tian-Ying Xu, **n-Zhu Liu, Sai-Long Zhang, Pei Wang… in Scientific Reports (2015)