-
Article
Publisher Correction: APOE4 homozygosity represents a distinct genetic form of Alzheimer’s disease
-
Article
Open AccessTau propagation in the brain olfactory circuits is associated with smell perception changes in aging
The direct access of olfactory afferents to memory-related cortical systems has inspired theories about the role of the olfactory pathways in the development of cortical neurodegeneration in Alzheimer’s diseas...
-
Article
APOE4 homozygosity represents a distinct genetic form of Alzheimer’s disease
This study aimed to evaluate the impact of APOE4 homozygosity on Alzheimer’s disease (AD) by examining its clinical, pathological and biomarker changes to see whether APOE4 homozygotes constitute a distinct, gene...
-
Article
Open AccessCortical microstructural changes predict tau accumulation and episodic memory decline in older adults harboring amyloid
Non-invasive diffusion-weighted imaging (DWI) to assess brain microstructural changes via cortical mean diffusivity (cMD) has been shown to be cross-sectionally associated with tau in cognitively normal older ...
-
Article
Open AccessCorrection: Plasma glial fibrillary acidic protein and neurofilament light chain for the diagnostic and prognostic evaluation of frontotemporal dementia
-
Article
Open AccessCorrection: Cortical microstructure in primary progressive aphasia: a multicenter study
-
Article
Open AccessNeural correlates of episodic memory in adults with Down syndrome and Alzheimer’s disease
Adults with Down syndrome are at an ultra-high risk of develo** early-onset Alzheimer’s disease. Episodic memory deficits are one of the earliest signs of the disease, but their association with regional bra...
-
Article
Open AccessCortical microstructure in primary progressive aphasia: a multicenter study
Cortical mean diffusivity is a novel imaging metric sensitive to early changes in neurodegenerative syndromes. Higher cortical mean diffusivity values reflect microstructural disorganization and have been prop...
-
Article
Open AccessPlasma glial fibrillary acidic protein and neurofilament light chain for the diagnostic and prognostic evaluation of frontotemporal dementia
Astrocytes play an essential role in neuroinflammation and are involved in the pathogenesis of neurodenegerative diseases. Studies of glial fibrillary acidic protein (GFAP), an astrocytic damage marker, may he...
-
Article
Open AccessAssociation of cortical microstructure with amyloid-β and tau: impact on cognitive decline, neurodegeneration, and clinical progression in older adults
Noninvasive biomarkers of early neuronal injury may help identify cognitively normal individuals at risk of develo** Alzheimer’s disease (AD). A recent diffusion-weighted imaging (DWI) method allows assessin...
-
Article
Open AccessDivergent connectomic organization delineates genetic evolutionary traits in the human brain
The relationship between human brain connectomics and genetic evolutionary traits remains elusive due to the inherent challenges in combining complex associations within cerebral tissue. In this study, insight...
-
Article
Open AccessRegional grey matter microstructural changes and volume loss according to disease duration in multiple sclerosis patients
The spatio-temporal characteristics of grey matter (GM) impairment in multiple sclerosis (MS) are poorly understood. We used a new surface-based diffusion MRI processing tool to investigate regional modificati...
-
Article
Open AccessPhosphorylated tau181 in plasma as a potential biomarker for Alzheimer’s disease in adults with Down syndrome
Plasma tau phosphorylated at threonine 181 (p-tau181) predicts Alzheimer’s disease (AD) pathology with high accuracy in the general population. In this study, we investigated plasma p-tau181 as a biomarker of ...
-
Article
Open AccessCerebrospinal fluid profile of NPTX2 supports role of Alzheimer’s disease-related inhibitory circuit dysfunction in adults with Down syndrome
Alzheimer’s disease (AD) is the major cause of death in adults with Down syndrome (DS). There is an urgent need for objective markers of AD in the DS population to improve early diagnosis and monitor disease p...
