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Article
Open AccessTau propagation in the brain olfactory circuits is associated with smell perception changes in aging
The direct access of olfactory afferents to memory-related cortical systems has inspired theories about the role of the olfactory pathways in the development of cortical neurodegeneration in Alzheimer’s diseas...
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Article
Open AccessSpatiotemporal patterns of locus coeruleus integrity predict cortical tau and cognition
Autopsy studies indicated that the locus coeruleus (LC) accumulates hyperphosphorylated tau before allocortical regions in Alzheimer’s disease. By combining in vivo longitudinal magnetic resonance imaging meas...
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Article
Open AccessMulti-modal Neuroimaging Phenoty** of Mnemonic Anosognosia in the Aging Brain
Unawareness is a behavioral condition characterized by a lack of self-awareness of objective memory decline. In the context of Alzheimer’s Disease (AD), unawareness may develop in predementia stages and contri...
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Article
Open AccessOpen datasets and code for multi-scale relations on structure, function and neuro-genetics in the human brain
The human brain is an extremely complex network of structural and functional connections that operate at multiple spatial and temporal scales. Investigating the relationship between these multi-scale connectio...
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Article
Open AccessCortical microstructural changes predict tau accumulation and episodic memory decline in older adults harboring amyloid
Non-invasive diffusion-weighted imaging (DWI) to assess brain microstructural changes via cortical mean diffusivity (cMD) has been shown to be cross-sectionally associated with tau in cognitively normal older ...
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Chapter and Conference Paper
Graph-Based Counterfactual Causal Inference Modeling for Neuroimaging Analysis
Alzheimer’s disease (AD) is a neurodegenerative disorder that is beginning with amyloidosis, followed by neuronal loss and deterioration in structure, function, and cognition. The accumulation of amyloid- ...
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Article
Open AccessNetwork hub centrality and working memory performance in schizophrenia
Cognitive impairment, and working memory deficits in particular, are debilitating, treatment-resistant aspects of schizophrenia. Dysfunction of brain network hubs, putatively related to altered neurodevelopmen...
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Article
Open AccessDivergent connectomic organization delineates genetic evolutionary traits in the human brain
The relationship between human brain connectomics and genetic evolutionary traits remains elusive due to the inherent challenges in combining complex associations within cerebral tissue. In this study, insight...
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Article
Early-life trauma endophenotypes and brain circuit–gene expression relationships in functional neurological (conversion) disorder
Functional neurological (conversion) disorder (FND) is a neuropsychiatric condition whereby individuals present with sensorimotor symptoms incompatible with other neurological disorders. Early-life maltreatmen...
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Article
Open AccessConnectivity adaptations in dopaminergic systems define the brain maturity of investors
Investment decisions rely on perceptions from external stimuli along with the integration of inner brain-body signals, all of which are shaped by experience. As experience is capable of molding both the struct...
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Article
Neurogenetic contributions to amyloid beta and tau spreading in the human cortex
Tau and amyloid beta (Aβ) proteins accumulate along neuronal circuits in Alzheimer’s disease. Unraveling the genetic background for the regional vulnerability of these proteinopathies can help in understanding...
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Article
Open AccessNeurogenetic profiles delineate large-scale connectivity dynamics of the human brain
Experimental and modeling work of neural activity has described recurrent and attractor dynamic patterns in cerebral microcircuits. However, it is still poorly understood whether similar dynamic principles exi...
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Chapter and Conference Paper
Temporal Excitation Patterns on the Cerebral Cortex as a Result of Migraine Modeling
The complex, highly individual, geometry of the cerebral cortex in humans presents a major challenge in studying the spreading of spontaneous neuronal activity. Recent computational advances [1] allow to simulate...
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Article
Open AccessA novel brain partition highlights the modular skeleton shared by structure and function
Elucidating the intricate relationship between brain structure and function, both in healthy and pathological conditions, is a key challenge for modern neuroscience. Recent progress in neuroimaging has helped ...
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Chapter and Conference Paper
A Real-Time Sound Recognition System in an Assisted Environment
This article focuses on the development of detection and classification system of environmental sounds in real-time in a typical home for persons with disabilities. Based on the extraction of acoustic characte...
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Chapter and Conference Paper
Identification of Sounds and Sensing Technology for Home-Care Applications
This article focuses on an analysis of the needs of Hearing Impaired People and on the development of a recognition of environmental sounds system in a typical home. Based on the extraction of acoustic charact...
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Chapter and Conference Paper
Real-Time Display Recognition System for Visually Impaired
Currently, electronic devices incorporating displays to present the information to the user are ubiquitous common, and visually impaired people might have problems to use these devices. This article focuses on...
