23 Result(s)
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Article
Solubilization of an angiotensin II binding site from rat liver
The high affinity binding sites for angiotensin II were solubilized from rat liver membranes by treatment with CHAPS. The binding protein was also partially purified by angiotensin III inhibitor-coupled Affi-g...
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Article
Evaluation of some flavonoids as potential bradykinin antagonists
Fourteen flavonoids were evaluated for their effects as potential bradykinin (BK) antagonists. The compounds were evaluated in severalin vitro andin vivo (oral administration) systems; inhibition of BK induced co...
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Article
Angiotensin II-mediated stimulation of phospholipase D in rabbit kidney proximal tubule cells
The present study was undertaken to demonstrate whether or not angiotensin II activates a phospholipase D in rabbit kidney proximal tubule cells. By measuring the formation of [3H]phosphatidic acid and [3H]phosph...
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Article
Lipid peroxidation inhibitory activity of some constituents isolated from the stem bark ofEucalyptus globulus
Twelve compounds with lipid peroxidation inhibitory activity were isolated from the stem bark ofE. globulus. Their structures were assigned as a new aromatic monoterpene (1) and eleven known compounds, pinoresino...
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Article
Pharmacological characterization of (10bS)-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline oxalate (YSL-3S) as a new α2-adrenoceptor antagonist
α2-Adrenoceptor antagonists, which can enhance synaptic norepinephrine levels by blocking feedback inhibition processes, are potentially useful in the treatment of disease states such as depression, memory impai....
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Article
Comparisons between white ginseng radix and rootlet for antidiabetic activity and mechanism in KKAy mice
The mechanisms responsible for the antidiabetic activity of both the white ginseng radix (Ginseng Radix Alba, GRA) and the rootlet (Ginseng Radix Palva, GRP) were investigated. After a four week oral administr...
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Article
Long-term administration of sopungsungi-won (SP) prevents diabetic nephropathy in zucker diabetic fatty rats
We investigated the long term effects of Sopungsungi-won (SP), a Korean traditional formula used for senile constipation and diabetes mellitus, on the development of diabetic nephropathy (DN) in Zucker diabeti...
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Article
Sopungsungi-won (SP) prevents the onset of hyperglycemia and hyperlipidemia in zucker diabetic fatty rats
Sopungsungi-won (SP) is a known formula for senile constipation and diabetes mellitus, based on traditional Korean medicine. The preventive effect of SP on the development of overt diabetes in Zucker diabetic ...
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Article
Anti-Inflammation activity ofActinidia polygama
The fruit of Actinidia polygama (AP) has long been used as a folk medicine in Korea for treating pain, rheumatic arthritis and inflammation. The present investigation was carried out to determine thein vivo andin...
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Article
Efficacy of Low-Dose Tamsulosin on Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Hyperplasia
To evaluate the efficacy and tolerability of tamsulosin 0.2mg once daily in Korean patients with lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia (BPH), who were treated for up to...
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Article
Wild ginseng prevents the onset of high-fat diet induced hyperglycemia and obesity in icr mice
Ginseng is a shade-loving perennial herb that is cultivated mainly in Korea, Japan, and China. The ginseng root has been used as a tonic remedy, and its antidiabetic activity has been demonstrated as early as ...
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Article
Antidiabetic coumarin and cyclitol compounds fromPeucedanum japonicum
The antidiabetic activity-guided fractionation and isolation of the 80% EtOH extracts from Peucedani Radix(Peucedanum japonicum, Umbelliferae) led to the isolation and characterization of a coumarin and a cyclito...
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Article
Antidiabetic stilbene and anthraquinone derivatives fromRheum undulatum
The antidiabetic-activity-guided fractionation and isolation of the 80% EtOH extracts obtained from cultivated Korean Rhubarb rhizomes (Rheum undulatum, Polygonaceae) led to the isolation and characterization of ...
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Article
Salicornia herbacea prevents high fat diet-induced hyperglycemia and hyperlipidemia in ICR mice
Salicornia herbacea L. (Chenopodiaceae) has been used as a seasoned vegetable by living in coastal areas.S. herbacea (SH) has been demonstrated to stimulate cytokine production, nitric ox...
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Article
Structure-activity relationships of dimethylsphingosine (DMS) derivatives and their effects on intracellular pH and Ca2+ in the U937 monocyte cell line
We recently reported that dimethylsphingosine (DMS), a metabolite of sphingolipids, increased intracellular pH and Ca2+ concentration in U937 human monocytes. In the present study, we found that dimethylphytosphi...
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Article
Acanthopanax senticosus reverses fatty liver disease and hyperglycemia in ob/ob mice
Non-alcoholic fatty liver disease (NAFLD) is common in obesity. However, weight reduction alone does not prevent the progression of NAFLD to end-stage disease associated with the development of cirrhosis and l...
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Vinegar- processed ginseng radix improves metabolic syndrome induced by a high fat diet in ICR mice
Ginseng has made a successful transition from the world of traditional tonic remedies to conventional medicine, and since the 1920s ginseng root has been documented to be effective in diabetes, hypertension, d...
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Article
In Vivo andIn Vitro anti-inflammatory activities of α-linolenic acid isolated from actinidia polygama fruits
The fruit ofActinidia polygama (AP) has long been used as a folk medicine in Korea for the treatment of pain, rheumatoid arthritis and inflammation. In the present study, bioassay-guided fractionation of AP led t...
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Article
AMP-activated protein kinase: A potential target for ginsenosides?
Panax ginseng is a best-selling medicinal plant showing an antidiabetic activity via human, animal and in vitro studies. Among bioactive constituents found in ginseng, ginsenosides are known to be responsible for...
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Article
Propofol Attenuates Pulmonary Injury Induced by Collapse and Reventilation of Lung in Rabbits
Propofol is an anesthetic drug with antioxidant and anti-inflammatory properties. We previously found that propofol attenuated lipopolysaccharide-induced acute lung injury in rabbits. This study was performed ...
