13 Result(s)
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Open AccessCortico-striatal differences in the epigenome in attention-deficit/ hyperactivity disorder
While epigenetic modifications have been implicated in ADHD through studies of peripheral tissue, to date there has been no examination of the epigenome of the brain in the disorder. To address this gap, we ma...
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Open AccessPolygenic scores for psychiatric disorders in a diverse postmortem brain tissue cohort
A new era of human postmortem tissue research has emerged thanks to the development of ‘omics technologies that measure genes, proteins, and spatial parameters in unprecedented detail. Also newly possible is t...
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Open AccessAntipsychotic drug use complicates assessment of gene expression changes associated with schizophrenia
Recent postmortem transcriptomic studies of schizophrenia (SCZ) have shown hundreds of differentially expressed genes. However, the extent to which these gene expression changes reflect antipsychotic drug (APD...
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Map** the cortico-striatal transcriptome in attention deficit hyperactivity disorder
Despite advances in identifying rare and common genetic variants conferring risk for ADHD, the lack of a transcriptomic understanding of cortico-striatal brain circuitry has stymied a molecular mechanistic und...
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Open AccessDeep transcriptome sequencing of subgenual anterior cingulate cortex reveals cross-diagnostic and diagnosis-specific RNA expression changes in major psychiatric disorders
Despite strong evidence of heritability and growing discovery of genetic markers for major mental illness, little is known about how gene expression in the brain differs across psychiatric diagnoses, or how kn...
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Role of gamma-amino-butyric acid in the dorsal anterior cingulate in age-associated changes in cognition
GABAergic mechanisms have been shown to contribute to cognitive aging in animal models, but there is currently limited in vivo evidence to support this relationship in humans. It is also unclear whether aging ...
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Effects of the BDNF Val66Met Polymorphism on White Matter Microstructure in Healthy Adults
The BDNF Val66Met polymorphism, a possible risk variant for mental disorders, is a potent modulator of neural plasticity in humans and has been linked to deficits in gray matter structure, function, and cognition...
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Effect of Schizophrenia Risk-Associated Alleles in SREB2 (GPR85) on Functional MRI Phenotypes in Healthy Volunteers
Genetic variants in GPR85 (SREB2: rs56080411 and rs56039557) have been associated with risk for schizophrenia. Here, we test the hypothesis that these variants impact on brain function in normal subjects, meas...
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Investigation of Anatomical Thalamo-Cortical Connectivity and fMRI Activation in Schizophrenia
The purpose of this study was to examine measures of anatomical connectivity between the thalamus and lateral prefrontal cortex (LPFC) in schizophrenia and to assess their functional implications. We measured ...
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Genetic Modulation of GABA Levels in the Anterior Cingulate Cortex by GAD1 and COMT
γ-Aminobutyric acid (GABA)-ergic transmission is critical for normal cortical function and is likely abnormal in a variety of neuropsychiatric disorders. We tested the in vivo effects of variations in two genes i...
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Nicotine-Induced Dopamine Release in Primates Measured with [11C]Raclopride PET
Nicotine-induced dopamine (DA) release constitutes a pharmacological probe of the DA system that has potential use in patients with schizophrenia, who have abnormally elevated DA release after amphetamine admi...
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Erratum: Comparison of Cognitive Peformances During a Placebo Period and an Atypical Antipsychotic Treatment Period in Schizophrenia: Critical Examination of Confounds
Correction to: Neuropsychopharmacology (2003) 28, 1491–1500. doi: 10.1038/sj.npp.1300216 Following publication of the above paper, the author has identified an error on page 1494. The correct statement should ...
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Comparison of Cognitive Performances During a Placebo Period and an Atypical Antipsychotic Treatment Period in Schizophrenia: Critical Examination of Confounds
Although previous studies report cognitive improvement following atypical antipsychotic administration in schizophrenia (SC), few placebo-controlled within-subject studies with examination of confounds (sympto...
