28 Result(s)

Article

Intricacies in the Preparation of Patient Doses of [¹⁷⁷Lu]Lu-Rituximab and [¹⁷⁷Lu]Lu-Trastuzumab Using Low Specific Activity [¹⁷⁷Lu]LuCl₃: Methodological Aspects

The development of humanized monoclonal antibodies (MAbs) with Lutetium-177 ([¹⁷⁷Lu]Lu³⁺) has brought a paradigm shift in the arena of targeted therapy of various cancers. [¹⁷⁷Lu]Lu-DOTA-Rituximab and [¹⁷⁷Lu]Lu-D...

Avik Chakraborty, Arpit Mitra, Sudeep Sahu, Megha Tawate… in Molecular Imaging and Biology (2024)

Article

Evaluation of Different Methods for the Detection of Anti- Thyroglobulin Autoantibody: Prevalence of Anti-Thyroglobulin Autoantibody and Anti-Microsomal Autoantibody in Thyroid Cancer Patients

Four anti-thyroglobulin autoantibodies (TgAb) assays were evaluated for their reference interval, method agreement, concordance etc. Prevalence of TgAb and anti-thyroid peroxidase was studied in differentiated...

Chandrakala Gholve, Archana Damle… in Indian Journal of Clinical Biochemistry (2022)

Article

On the production of pharmaceutical grade indium-111-chloride in the medical cyclotron from natural cadmium target and its use in formulation of diagnostic patient dose of ¹¹¹In-pentetreotide for imaging somatostatin receptor overexpression

A prototype, semi-automated, indigenous solid-target assembly has been developed to produce clinical grade ¹¹¹InCl₃ from ^natCd targets. Fluka Monte Carlo code was used to estimate the optimum proton energy range ...

Kanchan Kushwaha, Arpit Mitra… in Journal of Radioanalytical and Nuclear Che… (2021)

Article

Clinical efficacy of Sep-Pak^® assisted one pot automated synthesis of pharmaceutical grade [¹⁸F]FLT using 5′-O-(benzoyl)-2,3′-anhydrothymidine precursor

An automated production of pharmaceutical grade 3′-deoxy-3′-[¹⁸F]fluorothymidine ([¹⁸F]FLT) with solid phase extraction (SPE) purification using 5′-O-(Benzoyl)-2,3′anhydrothymidine precursor (Benzoyl-Anhydro) pos...

Arpit Mitra, Avik Chakraborty… in Journal of Radioanalytical and Nuclear Che… (2021)

Article

Availability of both [¹⁷⁷Lu]Lu-DOTA-TATE and [⁹⁰Y]Y-DOTATATE as PRRT agents for neuroendocrine tumors: can we evolve a rational sequential duo-PRRT protocol for large volume resistant tumors?

Sandip Basu, Rahul V. Parghane… in European Journal of Nuclear Medicine and M… (2020)

Article

Novel radioassay for anti-thyroperoxidase autoantibodies using protein A coupled magnetizable cellulose particles as an immunoadsorbent

Autoantibodies against thyroid peroxidase (TPO); described initially as thyroid microsomal antigen, are found in most of the patients with autoimmune thyroid disorders. The present study comprised of developme...

Chandrakala Gholve, Sharmila Banerjee… in Journal of Radioanalytical and Nuclear Che… (2020)

Article

Purification of ⁹⁹Mo and ^99mTc from radioactive traces of Nb, Zr, and Y impurities: method applicable in the purification of the spent ^100/99Mo–^99mTc generator

The aim of this work was to develop a method for purification of the spent ^100/99Mo–^99mTc generator free from non-isotopic impurities like Nb, Y, Zr and recovery of ^99mTc using a Sephadex column and MEK solvent e...

Sankha Chattopadhyay, Sujata Saha Das… in Journal of Radioanalytical and Nuclear Che… (2019)

Article

Comparison of Serum Thyroglobulin Levels in Differentiated Thyroid Cancer Patients Using In-House Developed Radioimmunoassay and Immunoradiometric Procedures

Thyroglobulin (Tg) is a proven tumor marker in the follow-up and post-operative management of patients with differentiated thyroid cancer (DTC). All assays for serum thyroglobulin (s-Tg) are based on immunoass...

Chandrakala Gholve, J. Kumarasamy, Archana Damle… in Indian Journal of Clinical Biochemistry (2019)

Article

Microarray immunoassay for thyrotropin on track-etched membranes using radiotracers

We report a microarray immunoassay for thyrotropin in serum using an anti-thyrotropin monoclonal ‘antibody-chip’ fabricated on polycarbonate track-etched membranes as a solid-support. The thyrotropin microarra...

Bharti Jain, Savita Kulkarni… in Journal of Radioanalytical and Nuclear Che… (2019)

Article

Preparation and preliminary evaluation of a tris-metronidazole-^99mTc(CO)₃ complex for targeting tumor hypoxia

Conventional ^99mTc-radiopharmaceuticals for the detection of tumor hypoxia generally possess a single nitroimidazole moiety. Herein, we report the synthesis and evaluation of a ^99mTc-complex with three-nitroimida...

Madhava B. Mallia, Anupam Mathur… in Journal of Radioanalytical and Nuclear Che… (2018)

Article

Synthesis of O-(1′-[¹⁸F]fluoropropan-2′-yl)-l-tyrosine (1-[¹⁸F]FPT) via Ni(II) complex of (S) tyrosine schiff’s base precursor

O-(1′-[¹⁸F]fluoropropan-2′-yl)-l-tyrosine (1-[¹⁸F]FPT) was synthesized using the Ni(II)-(S)-[N-2-(N′-benzylprolyl)amino]benzophenone-S-tyrosine based precursor. The precursor was synthesized through a two-step pr...

N. Lakshminarayanan, Sharmila Banerjee… in Journal of Radioanalytical and Nuclear Che… (2017)

Article

Envisaging an alpha therapy programme in the atomic energy establishments: the priorities and the nuances

Sandip Basu… in European Journal of Nuclear Medicine and Molecular Imaging (2017)

Article

Preparation and preliminary bioevaluation of ⁶⁸Ga-oxine in lipiodol as a potential liver imaging agent

Lipiodol functions as an embolizing agent for trans-arterial embolization and is used to deliver localized doses of chemotherapeutic drugs as well as ionizing radiation to cancerous tissue of the liver. Theref...

Subhajit Ghosh, Tapas Das, Haladhar D. Sarma… in Journal of Radioanalytical and Nuclear Che… (2017)

Article

Radiopharmaceuticals for metastatic bone pain palliation: available options in the clinical domain and their comparisons

Bone pain arising due to skeletal metastases is one of the common complications experienced by the majority of patients suffering from prostate, breast and lung cancer at the advanced stage of the disease. The...

Tapas Das, Sharmila Banerjee in Clinical & Experimental Metastasis (2017)

Article

Preparation and bioevaluation of [^99mTcN]²⁺-labeled tetrameric complex of E-c(RGDfK)₂ as a radiotracer for imaging α_vβ₃ integrins in tumors

The objective of the present work is to radiolabel a dimeric RGD peptide namely, E-c(RGDfK)₂ using [^99mTcN]²⁺ core in order to obtain a ^99mTc-labeled tetrameric RGD species, which is expected to have an enhanced ...

Mohini Guleria, Subhajit Ghosh, Tapas Das… in Journal of Radioanalytical and Nuclear Che… (2016)

Article

Convenient Preparation of [⁶⁸Ga]DKFZ-PSMA-11 Using a Robust Single-Vial Kit and Demonstration of Its Clinical Efficacy

[⁶⁸Ga]DKFZ-PSMA-11 has proved to be an important diagnostic radiotracer for targeting prostate-specific membrane antigen (PSMA) overexpression in both recurrent prostate cancer (PC) and relevant metastatic sites....

Drishty Satpati, Ajit Shinto, K. K. Kamaleshwaran… in Molecular Imaging and Biology (2016)

Article

Synthesis and evaluation of a novel ^99mTcN(PNP)-complex with metronidazole isocyanide ligand as a marker for tumor hypoxia

The [^99mTcN(PNP)]²⁺ core offers a unique route for the preparation of asymmetric ^99mTc-complexes. Though bidentate chelators such as dithiocarbamates are most commonly used ligands in this approach, present study...

Kusum Vats, Madhava B. Mallia, Anupam Mathur… in Journal of Radioanalytical and Nuclear Che… (2016)