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  1. No Access

    Article

    Tumor-associated myeloid cells: diversity and therapeutic targeting

    Myeloid cells in tumor tissues constitute a dynamic immune population characterized by a non-uniform phenotype and diverse functional activities. Both tumor-associated macrophages (TAMs), which are more abunda...

    Alberto Mantovani, Federica Marchesi, Sebastien Jaillon… in Cellular & Molecular Immunology (2021)

  2. No Access

    Article

    Complement activation promoted by the lectin pathway mediates C3aR-dependent sarcoma progression and immunosuppression

    Complement has emerged as a component of tumor-promoting inflammation. We conducted a systematic assessment of the role of complement activation and effector pathways in sarcomas. C3−/−, MBL1/2−/− and C4−/− mice ...

    Elena Magrini, Sabrina Di Marco, Sarah N. Mapelli, Chiara Perucchini… in Nature Cancer (2021)

  3. No Access

    Article

    Neutrophil diversity and plasticity in tumour progression and therapy

    Neutrophils play a key role in defence against infection and in the activation and regulation of innate and adaptive immunity. In cancer, tumour-associated neutrophils (TANs) have emerged as an important compo...

    Sebastien Jaillon, Andrea Ponzetta, Diletta Di Mitri… in Nature Reviews Cancer (2020)

  4. No Access

    Article

    Sexual Dimorphism in Innate Immunity

    Sexual dimorphisms account for differences in clinical manifestations or incidence of infectious or autoimmune diseases and malignancy between females and males. Females develop enhanced innate and adaptive im...

    Sébastien Jaillon, Kevin Berthenet… in Clinical Reviews in Allergy & Immunology (2019)

  5. No Access

    Article

    IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity

    Interleukin-1 receptor 8 (IL-1R8), a negative regulator of the IL-1 family of cytokines, restrains the activity of natural killer (NK) cells, suggesting that IL-1R8 acts as a checkpoint regulator of NK cell ac...

    Martina Molgora, Eduardo Bonavita, Andrea Ponzetta, Federica Riva… in Nature (2017)

  6. No Access

    Reference Work Entry In depth

    Pentraxins

    Sébastien Jaillon, Antonio Inforzato… in Compendium of Inflammatory Diseases (2016)

  7. No Access

    Living Reference Work Entry In depth

    Pentraxins

    Sébastien Jaillon, Antonio Inforzato… in Encyclopedia of Inflammatory Diseases

  8. No Access

    Article

    Neutrophils in innate and adaptive immunity

    Neutrophils have long been viewed as short-lived cells crucial for the elimination of extracellular pathogens, possessing a limited role in the orchestration of the immune response. This dogma has been challen...

    Sébastien Jaillon, Maria Rosaria Galdiero, Davide Del Prete… in Seminars in Immunopathology (2013)

  9. No Access

    Article

    Neutrophils in the activation and regulation of innate and adaptive immunity

  10. Neutrophils have long been viewed as short-lived effector cells of the innate immune system, with a primary role in resistance against extracellular pathogens ...

    11. Alberto Mantovani, Marco A. Cassatella, Claudio Costantini… in Nature Reviews Immunology (2011)

  11. Article

    Pentraxins in innate immunity: lessons from PTX3

    The innate immune system constitutes the first line of defence against microorganisms and plays a primordial role in the activation and regulation of adaptive immunity. The innate immune system is composed of ...

    Livija Deban, Sebastien Jaillon, Cecilia Garlanda… in Cell and Tissue Research (2011)

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  12. No Access

    Chapter

    Heat Shock Proteins and Scavenger Receptors

    Cytosolic heat shock proteins and endoplasmic reticulum resident chaperones (collectively referred as to Heat Shock Proteins or HSPs) control the folding and prevent the aggregation of proteins. Tumor-derived HSP

    Yves Delneste, Sébastien Jaillon… in Heat Shock Proteins: Potent Mediators of I… (2007)