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Open AccessAuthor Correction: Bridging of host-microbiota tryptophan partitioning by the serotonin pathway in fungal pneumonia
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Article
Open AccessA microbially produced AhR ligand promotes a Tph1-driven tolerogenic program in multiple sclerosis
Multiple sclerosis is a debilitating autoimmune disease, characterized by chronic inflammation of the central nervous system. While the significance of the gut microbiome on multiple sclerosis pathogenesis is ...
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Article
Open AccessResilience improvement through a multicomponent physical and cognitive intervention for older people: the DanzArTe emotional well-being technology project
Resilience is a crucial component of successful aging. However, which interventions might increase resilience in older adults is yet unclear.
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Article
Open AccessDual species sphingosine-1-phosphate lyase inhibitors to combine antifungal and anti-inflammatory activities in cystic fibrosis: a feasibility study
Cystic fibrosis (CF) is an autosomal recessive disorder characterized by respiratory failure due to a vicious cycle of defective Cystic Fibrosis Transmembrane conductance Regulator (CFTR) function, chronic inf...
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Article
Open AccessBridging of host-microbiota tryptophan partitioning by the serotonin pathway in fungal pneumonia
The aromatic amino acid L-tryptophan (Trp) is essentially metabolized along the host and microbial pathways. While much is known about the role played by downstream metabolites of each pathways in intestinal h...
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Article
Reply to ‘F508del-CFTR is not corrected by thymosin α1’
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Article
slanDCs selectively accumulate in carcinoma-draining lymph nodes and marginate metastatic cells
Dendritic cells (DCs) initiate adaptive immune responses to cancer cells by activating naive T lymphocytes. 6-sulfo LacNAc+ DCs (slanDCs) represent a distinct population of circulating and tissue proinflammatory ...
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Article
Neutrophils in the activation and regulation of innate and adaptive immunity
Neutrophils have long been viewed as short-lived effector cells of the innate immune system, with a primary role in resistance against extracellular pathogens ...
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Article
Astrocytes Regulate the Expression of Insulin-Like Growth Factor 1 Receptor (IGF1-R) in Primary Cortical Neurons During In Vitro Senescence
The role of insulin-like growth factor 1 (IGF1) pathway as regulator of aging and age-related diseases is increasingly recognized. Recent evidence has been provided that neuronal IGF1-R increases during aging ...
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Article
Characterization of the signaling pathway downstream p75 neurotrophin receptor involved in β-amyloid peptide-dependent cell death
The accumulation of β-amyloid (Aβ) peptide is a key pathogenic event in Alzheimer’s disease. Previous studies have shown that Aβ peptide can damage neurons by activating the p75 neurotrophin receptor (p75NTR). Ho...
