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Article
Tumor-associated myeloid cells: diversity and therapeutic targeting
Myeloid cells in tumor tissues constitute a dynamic immune population characterized by a non-uniform phenotype and diverse functional activities. Both tumor-associated macrophages (TAMs), which are more abunda...
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Article
Complement activation promoted by the lectin pathway mediates C3aR-dependent sarcoma progression and immunosuppression
Complement has emerged as a component of tumor-promoting inflammation. We conducted a systematic assessment of the role of complement activation and effector pathways in sarcomas. C3−/−, MBL1/2−/− and C4−/− mice ...
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Article
Neutrophil diversity and plasticity in tumour progression and therapy
Neutrophils play a key role in defence against infection and in the activation and regulation of innate and adaptive immunity. In cancer, tumour-associated neutrophils (TANs) have emerged as an important compo...
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Article
Sexual Dimorphism in Innate Immunity
Sexual dimorphisms account for differences in clinical manifestations or incidence of infectious or autoimmune diseases and malignancy between females and males. Females develop enhanced innate and adaptive im...
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Article
IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity
Interleukin-1 receptor 8 (IL-1R8), a negative regulator of the IL-1 family of cytokines, restrains the activity of natural killer (NK) cells, suggesting that IL-1R8 acts as a checkpoint regulator of NK cell ac...
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Reference Work Entry In depth
Pentraxins
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Living Reference Work Entry In depth
Pentraxins
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Article
Neutrophils in innate and adaptive immunity
Neutrophils have long been viewed as short-lived cells crucial for the elimination of extracellular pathogens, possessing a limited role in the orchestration of the immune response. This dogma has been challen...
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Article
Neutrophils in the activation and regulation of innate and adaptive immunity
Neutrophils have long been viewed as short-lived effector cells of the innate immune system, with a primary role in resistance against extracellular pathogens ...
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Article
Pentraxins in innate immunity: lessons from PTX3
The innate immune system constitutes the first line of defence against microorganisms and plays a primordial role in the activation and regulation of adaptive immunity. The innate immune system is composed of ...
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Chapter
Heat Shock Proteins and Scavenger Receptors
Cytosolic heat shock proteins and endoplasmic reticulum resident chaperones (collectively referred as to Heat Shock Proteins or HSPs) control the folding and prevent the aggregation of proteins. Tumor-derived HSP