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  1. Article

    Open Access

    Chemotherapy-induced COX-2 upregulation by cancer cells defines their inflammatory properties and limits the efficacy of chemoimmunotherapy combinations

    Cytotoxic therapies, besides directly inducing cancer cell death, can stimulate immune-dependent tumor growth control or paradoxically accelerate tumor progression. The underlying mechanisms dictating these op...

    Charlotte R. Bell, Victoria S. Pelly, Agrin Moeini… in Nature Communications (2022)

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    Article

    IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity

    Interleukin-1 receptor 8 (IL-1R8), a negative regulator of the IL-1 family of cytokines, restrains the activity of natural killer (NK) cells, suggesting that IL-1R8 acts as a checkpoint regulator of NK cell ac...

    Martina Molgora, Eduardo Bonavita, Andrea Ponzetta, Federica Riva… in Nature (2017)