218 Result(s)
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Open AccessPopulation structure and selection signal analysis of indigenous sheep from the southern edge of the Taklamakan Desert
Analyzing the genetic diversity and selection characteristics of sheep (Ovis aries) holds significant value in understanding their environmental adaptability, enhancing breeding efficiency, and achieving effec...
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Open AccessIntegration of large and diverse angiosperm DNA fragments into Asian Gnetum mitogenomes
Horizontal gene transfer (HGT) events have rarely been reported in gymnosperms. Gnetum is a gymnosperm genus comprising 25‒35 species sympatric with angiosperms in West African, South American, and Southeast Asia...
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Mendelian randomization evidence for the causal effect of mental well-being on healthy aging
Mental well-being relates to multitudinous lifestyle behaviours and morbidities and underpins healthy aging. Thus far, causal evidence on whether and in what pattern mental well-being impacts healthy aging and...
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Structure of a histone hexamer bound by the chaperone domains of SPT16 and MCM2
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Computational tools for plant genomics and breeding
Plant genomics and crop breeding are at the intersection of biotechnology and information technology. Driven by a combination of high-throughput sequencing, molecular biology and data science, great advances h...
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Open AccessEstablishment of an in vitro model of monocyte-like THP-1 cells for trained immunity induced by bacillus Calmette-Guérin
Mycobacteria bloodstream infections are common in immunocompromised people and usually have disastrous consequences. As the primary phagocytes in the bloodstream, monocytes and neutrophils play critical roles ...
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Open AccessThrombomodulin reduces α-synuclein generation and ameliorates neuropathology in a mouse model of Parkinson’s disease
The neurotoxic α-synuclein (α-syn) oligomers play an important role in the occurrence and development of Parkinson’s disease (PD), but the factors affecting α-syn generation and neurotoxicity remain unclear. W...
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Open AccessKaryotype and LTR-RTs analysis provide insights into oak genomic evolution
Whole-genome duplication and long terminal repeat retrotransposons (LTR-RTs) amplification in organisms are essential factors that affect speciation, local adaptation, and diversification of organisms. Underst...
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Structure and assembly of the α-carboxysome in the marine cyanobacterium Prochlorococcus
Carboxysomes are bacterial microcompartments that encapsulate the enzymes RuBisCO and carbonic anhydrase in a proteinaceous shell to enhance the efficiency of photosynthetic carbon fixation. The self-assembly ...
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Open AccessActivation of GPR81 by lactate drives tumour-induced cachexia
Cachexia affects 50–80% of patients with cancer and accounts for 20% of cancer-related death, but the underlying mechanism driving cachexia remains elusive. Here we show that circulating lactate levels positiv...
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Open AccessArnicolide D induces endoplasmic reticulum stress-mediated oncosis via ATF4 and CHOP in hepatocellular carcinoma cells
Endoplasmic reticulum (ER) stress can trigger various cell death mechanisms beyond apoptosis, providing promise in cancer treatment. Oncosis, characterized by cellular swelling and increased membrane permeabil...
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The correct name for Gentiana albomarginata (Gentianaceae: Gentianeae)
Gentiana albomarginata C.Marquand was proposed as a replacement name for G. albescens (Franch.) Franch. ex Kusn., which was long considered as a later homonym of G. albescens Favre. However, G. albescens Favre w...
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Open AccessIL-8 activates fibroblasts to promote the invasion of HNSCC cells via STAT3-MMP1
Matrix metalloproteinase-1 (MMP1) has an aberrant expression relevant to various behaviors of cancers. As dominant components of the tumor stroma, fibroblasts constitute an important source of Matrix metallopr...
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LncRNA LY6E-DT and its encoded metastatic-related protein play oncogenic roles via different pathways and promote breast cancer progression
Abnormal long noncoding RNA (lncRNA) expression plays an important role in tumor invasion and metastasis. Here, we show that lncRNA LY6E divergent transcript (LY6E-DT) levels are increased in breast cancer (BC...
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Article
Ecological filtering shapes the impacts of agricultural deforestation on biodiversity
The biodiversity impacts of agricultural deforestation vary widely across regions. Previous efforts to explain this variation have focused exclusively on the landscape features and management regimes of agricu...
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Open AccessNMDARs activation regulates endothelial ferroptosis via the PP2A-AMPK-HMGB1 axis
N-methyl-D-aspartate receptors (NMDARs) are ligand-gated, voltage-dependent channels of the ionotropic glutamate receptor family. The present study explored whether NMDAR activation induced ferroptosis in vasc...
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Open AccessTargeting the E2F1/Rb/HDAC1 axis with the small molecule HR488B effectively inhibits colorectal cancer growth
Colorectal cancer (CRC), the third most common cancer worldwide, remains highly lethal as the disease only becomes symptomatic at an advanced stage. Growing evidence suggests that histone deacetylases (HDACs),...
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Open AccessPD-1 signaling negatively regulates the common cytokine receptor γ chain via MARCH5-mediated ubiquitination and degradation to suppress anti-tumor immunity
Combination therapy with PD-1 blockade and IL-2 substantially improves anti-tumor efficacy comparing to monotherapy. The underlying mechanisms responsible for the synergistic effects of the combination therapy...
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Open AccessRGS5 maintaining vascular homeostasis is altered by the tumor microenvironment
Regulator of G protein signaling 5 (RGS5), as a negative regulator of G protein-coupled receptor (GPCR) signaling, is highly expressed in arterial VSMCs and pericytes, which is involved in VSMC phenotypic hete...
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Tubular TMEM16A promotes tubulointerstitial fibrosis by suppressing PGC-1α-mediated mitochondrial homeostasis in diabetic kidney disease
Tubulointerstitial fibrosis (TIF) plays a crucial role in the progression of diabetic kidney disease (DKD). However, the underlying molecular mechanisms remain obscure. The present study aimed to examine wheth...
