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  1. Article

    Open Access

    PD-1 signaling negatively regulates the common cytokine receptor γ chain via MARCH5-mediated ubiquitination and degradation to suppress anti-tumor immunity

    Combination therapy with PD-1 blockade and IL-2 substantially improves anti-tumor efficacy comparing to monotherapy. The underlying mechanisms responsible for the synergistic effects of the combination therapy...

    Rui Liu, Lin-Wen Zeng, Hui-Fang Li, Jun-Ge Shi, Bo Zhong, Hong-Bing Shu… in Cell Research (2023)

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