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Article
3D bioengineered neural tissue generated from patient-derived iPSCs mimics time-dependent phenotypes and transcriptional features of Alzheimer’s disease
Several iPSC-derived three-dimensional (3D) cultures have been generated to model Alzheimer’s disease (AD). While some AD-related phenotypes have been identified across these cultures, none of them could recap...
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Article
Open AccessDifferential splicing of neuronal genes in a Trem2*R47H mouse model mimics alterations associated with Alzheimer’s disease
Molecular characterization of late-onset Alzheimer’s disease (LOAD), the leading cause of age-related dementia, has revealed transcripts, proteins, and pathway alterations associated with disease. Assessing th...
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Protocol
A Protocol for Horizontally Acquired Metabolic Gene Detection in Algae
Horizontal gene transfer (HGT) or lateral gene transfer (LGT), the exchange of genetic materials among organisms by means of other than parent-to-offspring (vertical) inheritance, plays a major role in prokary...
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Chapter
Synthesis, Characterization, and Evaluation of Toxicity of Melatonin-Loaded Poly (D,L-Lactic Acid) Nanoparticles (Mel-PLA-Nanoparticles) and Its Putative Use in Osteoporosis
Melatonin-loaded PLA nanoparticles are nowadays important in biological system for its biodegradable nature for targeted drug delivery. Hence, aim of the study is to note applicability and toxicity of Mel-PLA ...
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Article
Open AccessGenetic perturbations of disease risk genes in mice capture transcriptomic signatures of late-onset Alzheimer’s disease
New genetic and genomic resources have identified multiple genetic risk factors for late-onset Alzheimer’s disease (LOAD) and characterized this common dementia at the molecular level. Experimental studies in ...
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Article
Impact of Calotropis procera and Annona squamosa Alcoholic Extracts on Phosphatases and Transaminases Activities in Musca domestica
In the present study, the crude ethanol extracts of leaves of Calotropis procera and Annona squamosa have been screened for their insecticidal activities against Musca domestica (a housefly). The third instar la...
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Article
Deciphering evolutionary strata on plant sex chromosomes and fungal mating-type chromosomes through compositional segmentation
Sex chromosomes have evolved from a pair of homologous autosomes which differentiated into sex determination systems, such as XY or ZW system, as a consequence of successive recombination suppression between t...
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Article
Sulphur Dioxide Induced Alterations in Glycogen Metabolism in Rattus norvegicus
Present study has been undertaken with an aim to assess the effect of sulphur dioxide exposure on the glycogen metabolic pathway of albino rat, Rattus norvegicus. Animal was exposed to two different doses of SO2 ...
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Article
Assessment of acute toxicity of λ-cyhalothrin to a freshwater catfish, Clarias batrachus
Acute static bioassays were conducted for 96 h period with λ-cyhalothrin to determine its acute toxicity to a freshwater catfish, Clarias batrachus. The 96 h LC50 value was estimated to be 5.00 μg l−1 (95% confid...
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Article
Analysis of some heavy metals in the riverine water, sediments and fish from river Ganges at Allahabad
The river Ganges has been one of the major recipients of industrial effluents in India. The present paper deals with the study related to occurrence and bioaccumulation of heavy metals (Cu, Cr, Cd, Pb, Zn) in ...
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Article
Acetylcholinesterase: a potential biochemical indicator for biomonitoring of fertilizer industry effluent toxicity in freshwater teleost, Channa striatus
Monitoring of acetylcholinesterase (EC: 3.1.1.7, AChE) activity has been widely used in aquatic and terrestrial systems as an indicator of pollutant exposure. The reports regarding impact of fertilizer industr...
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Article
Open AccessMolecular characterization of senescence marker protein-30 gene promoter: Identification of repressor elements and functional nuclear factor binding sites
Senescence marker protein-30 (SMP30), whose expression declines during aging in rat liver, has been proposed as an important aging marker. Besides apoptosis, SMP30 also protects cells against various other inj...
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Article
Fertilizer Industry Effluent Induced Biochemical Changes in Fresh water Teleost, Channa striatus (Bloch)
The industrial activities pose threat to the life of aquatic organisms in many ways. This research communication presents an account of the impact of fertilizer industry effluent upon the levels of protein and...
