-
Article
Seasonal plasticity in immunocompetent cytokines (IL-2, IL-6, and TNF-α), myeloid progenitor cell (CFU-GM) proliferation, and LPS-induced oxido-inflammatory aberrations in a tropical rodent Funambulus pennanti: role of melatonin
In seasonal breeders, photoperiods regulate the levels of circulatory melatonin, a well-known immunomodulator and an antioxidant. Melatonin is known to play a complex physiological role in maintaining the immu...
-
Chapter
Melatonin: A Saga of Health and Longevity
Melatonin, an indoleamine neurohormone produced during night-time from the pineal gland, is the master regulator of the circadian timing system and activity-rest rhythm in human beings. Melatonin is exceptiona...
-
Article
Lactate-Dependent Cross-Talk Between Astrocyte and GnRH-I Neurons in Hypothalamus of Aged Brain: Decreased GnRH-I Transcription
GnRH-I produced by hypothalamic neurosecretory cells is considered a master regulator of mammalian reproduction. Although GnRH-I transcription is well studied, the effect of ageing on transcriptional regulatio...
-
Article
Melatonin induces apoptosis and cell cycle arrest in cervical cancer cells via inhibition of NF-κB pathway
Cervical cancer is the most prevalent cancer in females. Melatonin, a neurohormone has been documented as a promising therapeutic molecule for cervical cancer. However, the underlying molecular mechanism is no...
-
Article
Continuous artificial light potentially disrupts central and peripheral reproductive clocks leading to altered uterine physiology and reduced pregnancy success in albino mice
The mechanism behind clock coordination in female reproductive disorders is poorly understood despite the known importance of coordinated and synchronized timing of central and clocks in reproductive organs. W...
-
Article
Melatonin Ameliorates LPS-Induced Testicular Nitro-oxidative Stress (iNOS/TNFα) and Inflammation (NF-kB/COX-2) via Modulation of SIRT-1
Lipopolysaccharide (LPS) — an endotoxin that is being extensively used in laboratory to mimic microbial infection that adversely affects male fertility. This study investigated the protective effects of melato...
-
Article
Fluoride Compromises Testicular Redox Sensor, Gap Junction Protein, and Metabolic Status: Amelioration by Melatonin
The excess fluoride intake has been shown to adversely affect male reproductive health. The aim of the present study was to investigate the key mechanism underlying fluoride-induced testicular dysfunction and ...
-
Article
Expression of Melatonin and Glucocorticoid Receptor Varies along with Lung-Associated Cell-Mediated Immunity in the Jungle Bush Quail Perdicula asiatica: a Trade-off between Melatonin and Dexamethasone
The role of circulatory glucocorticoids along with melatonin in the regulation of lung-associated cell-mediated immunity has never been explored in any tropical bird. This could be interesting because glucocor...
-
Chapter
Synthesis, Characterization, and Evaluation of Toxicity of Melatonin-Loaded Poly (D,L-Lactic Acid) Nanoparticles (Mel-PLA-Nanoparticles) and Its Putative Use in Osteoporosis
Melatonin-loaded PLA nanoparticles are nowadays important in biological system for its biodegradable nature for targeted drug delivery. Hence, aim of the study is to note applicability and toxicity of Mel-PLA ...
-
Article
Me11b receptor mediated action of melatonin in regulation of lung associated immune system (LAIS) of Perdicula asiatica: An in vitro study
The pineal hormone melatonin plays an important role in immunomodulation of avian species. These immunomodulatory effects of melatonin are known to be mediated by three membrane bound receptors found in birds,...
-
Article
Nycthemeral variation in melatonin receptor expression in the lymphoid organs of a tropical seasonal breeder Funambulus pennanti
Seasonal variations in immune functions point toward the involvement of melatonin in its regulation. These chronobiotic effects are exerted by receptors present on the immunocompetent cells. The present study ...
-
Article
Daily variations in plasma melatonin and melatonin receptor (MT1), PER1 and CRY1 expression in suprachiasmatic nuclei of tropical squirrel, Funambulus pennanti
The suprachiasmatic nucleus (SCN) plays a major role in photoperiodic regulation of seasonal functions by modulating the melatonin signal. To date no report exists regarding the role of the ambient photoperiod...
-
Article
Development of ciprofloxacin hydrochloride loaded poly(ethylene glycol)/chitosan scaffold as wound dressing
A novel ciprofloxacin hydrochloride loaded chitosan/poly(ethylene glycol) (PEG) composite scaffold was developed for wound dressing application. PEG incorporation in chitosan scaffold showed enhanced loading u...
-
Chapter
Biodegradable Polymers for Potential Delivery Systems for Therapeutics
Biodegradable polymers are being extensively used with great interest in areas of nanobiotechnology such as drug delivery, diagnostics, and other applications for clinical and biomedical research covering card...
-
Article
l-5-hydroxytryptophan resets the circadian locomotor activity rhythm of the nocturnal Indian pygmy field mouse, Mus terricolor
We report that l-5-hydroxytryptophan (5-HTP), a serotonin precursor, resets the overt circadian rhythm in the Indian pygmy field mouse, Mus terricolor, in a phase- and dose-dependent manner. We used wheel running...
-
Article
Effect of intra-testicular melatonin injection on testicular functions, local and general immunity of a tropical rodent Funambulus pennanti
Local antigonadotrophic action of melatonin in testes has never been correlated with local and general immune status of any rodent. Intra-testicular injection of melatonin (2.5 μg/50 μl) for 10 days (MI-10D) a...
-
Article
Open AccessModulation of immunity in young-adult and aged squirrel, Funambulus pennanti by melatonin and p-chlorophenylalanine
Our interest was to find out whether pineal gland and their by melatonin act as modulator of immunosenescence. Parachlorophenylalanine (PCPA) – a β adrenergic blocker, is known to perform chemical pinealectomy...
