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Article
Open AccessDifferential splicing of neuronal genes in a Trem2*R47H mouse model mimics alterations associated with Alzheimer’s disease
Molecular characterization of late-onset Alzheimer’s disease (LOAD), the leading cause of age-related dementia, has revealed transcripts, proteins, and pathway alterations associated with disease. Assessing th...
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Article
Open AccessVascular derived endothelin receptor A controls endothelin-induced retinal ganglion cell death
Endothelin (EDN, also known as ET) signaling has been suggested to be an important mediator of retinal ganglion cell (RGC) death in glaucoma. Antagonism of EDN receptors (EDNRA and EDNRB, also known as ET-A an...
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Article
Open AccessTranscriptional control of retinal ganglion cell death after axonal injury
Injury to the axons of retinal ganglion cells (RGCs) is a key pathological event in glaucomatous neurodegeneration. The transcription factors JUN (the target of the c-Jun N-terminal kinases, JNKs) and DDIT3/CH...
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Article
Open AccessComplement peptide C3a receptor 1 promotes optic nerve degeneration in DBA/2J mice
The risk of glaucoma increases significantly with age and exposure to elevated intraocular pressure, two factors linked with neuroinflammation. The complement cascade is a complex immune process with many bioa...
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Article
Open AccessA novel systems biology approach to evaluate mouse models of late-onset Alzheimer’s disease
Late-onset Alzheimer’s disease (LOAD) is the most common form of dementia worldwide. To date, animal models of Alzheimer’s have focused on rare familial mutations, due to a lack of frank neuropathology from mo...
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Article
Open AccessEndothelin 1-induced retinal ganglion cell death is largely mediated by JUN activation
Glaucoma is a neurodegenerative disease characterized by loss of retinal ganglion cells (RGCs), the output neurons of the retina. Multiple lines of evidence show the endothelin (EDN, also known as ET) system i...
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Article
Open AccessA novel mouse model expressing human forms for complement receptors CR1 and CR2
The complement cascade is increasingly implicated in development of a variety of diseases with strong immune contributions such as Alzheimer’s disease and Systemic Lupus Erythematosus. Mouse models have been u...
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Article
Open AccessGenetic perturbations of disease risk genes in mice capture transcriptomic signatures of late-onset Alzheimer’s disease
New genetic and genomic resources have identified multiple genetic risk factors for late-onset Alzheimer’s disease (LOAD) and characterized this common dementia at the molecular level. Experimental studies in ...
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Article
Open AccessTranscriptional profiling predicts running promotes cerebrovascular remodeling in young but not midlife mice
The incidence of dementia and cognitive decline is increasing with no therapy or cure. One of the reasons treatment remains elusive is because there are various pathologies that contribute to age-related cogni...
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Article
Open AccessIncreased interactions and engulfment of dendrites by microglia precede Purkinje cell degeneration in a mouse model of Niemann Pick Type-C
Niemann Pick Type-C disease (NPC) is an inherited lysosomal storage disease (LSD) caused by pathogenic variants in the Npc1 or Npc2 genes that lead to the accumulation of cholesterol and lipids in lysosomes. NPC1...
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Article
Open AccessTranscriptome profiling of brain myeloid cells revealed activation of Itgal, Trem1, and Spp1 in western diet-induced obesity
Environmental factors are critical in the development of age-related cognitive decline and dementia. A western diet (WD) can cause nutrient deficiency and inflammation that could impact cognition directly. It ...
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Article
Open AccessInhibition of monocyte-like cell extravasation protects from neurodegeneration in DBA/2J glaucoma
Glaucoma is characterized by the progressive dysfunction and loss of retinal ganglion cells. Recent work in animal models suggests that a critical neuroinflammatory event damages retinal ganglion cell axons in...
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Article
Open AccessInhibition of the classical pathway of the complement cascade prevents early dendritic and synaptic degeneration in glaucoma
Glaucoma is a complex, multifactorial disease characterised by the loss of retinal ganglion cells and their axons leading to a decrease in visual function. The earliest events that damage retinal ganglion cell...
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Article
Open AccessChronic consumption of a western diet induces robust glial activation in aging mice and in a mouse model of Alzheimer’s disease
Studies have assessed individual components of a western diet, but no study has assessed the long-term, cumulative effects of a western diet on aging and Alzheimer’s disease (AD). Therefore, we have formulated...
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Article
Correction: Corrigendum: A common variant map** to CACNA1A is associated with susceptibility to exfoliation syndrome
Nat. Genet. 47, 387–392 (2015); published online 23 February 2015; corrected online 9 March 2015; corrected after print 27 April 2015 In the version of this article initially published, the name of author Afsa...
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Article
A common variant map** to CACNA1A is associated with susceptibility to exfoliation syndrome
Tin Aung, Chiea-Chuen Khor and colleagues report the results of a genome-wide association study of exfoliation syndrome. They replicate a known association at LOXL1 and identify a previously unreported associatio...
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Article
Open AccessClustering of transcriptional profiles identifies changes to insulin signaling as an early event in a mouse model of Alzheimer’s disease
Alzheimer’s disease affects more than 35 million people worldwide but there is no known cure. Age is the strongest risk factor for Alzheimer’s disease but it is not clear how age-related changes impact the dis...
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Article
Open AccessDeficiency of complement component 5 ameliorates glaucoma in DBA/2J mice
Glaucoma is an age-related neurodegenerative disorder involving the loss of retinal ganglion cells (RGCs), which results in blindness. Studies in animal models have shown that activation of inflammatory proces...
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Article
High throughput sequencing approaches to mutation discovery in the mouse
Phenotype-driven approaches in mice are powerful strategies for the discovery of genes and gene functions and for unravelling complex biological mechanisms. Traditional methods for mutation discovery are relia...
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Article
Open AccessDatgan, a reusable software system for facile interrogation and visualization of complex transcription profiling data
We introduce Glaucoma Discovery Platform (GDP), an online environment for facile visualization and interrogation of complex transcription profiling datasets for glaucoma. We also report the availability of Dat...
