Retail Marketing and Sales Performance
A Definitive Guide to Optimizing Service Quality and Sales Effectiveness
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Open AccessGenetically diverse mouse models of SARS-CoV-2 infection reproduce clinical variation in type I interferon and cytokine responses in COVID-19
Inflammation in response to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection drives severity of coronavirus disease 2019 (COVID-19) and is influenced by host genetics. To understand mecha...
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Open AccessA novel human tau knock-in mouse model reveals interaction of Abeta and human tau under progressing cerebral amyloidosis in 5xFAD mice
Hyperphosphorylation and intraneuronal aggregation of the microtubule-associated protein tau is a major pathological hallmark of Alzheimer’s disease (AD) brain. Of special interest is the effect of cerebral am...
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Open AccessAuthor Correction: Molecular estimation of neurodegeneration pseudotime in older brains
A Correction to this paper has been published: https://doi.org/10.1038/s41467-020-20261-6
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Article
Open AccessMolecular estimation of neurodegeneration pseudotime in older brains
The temporal molecular changes that lead to disease onset and progression in Alzheimer’s disease (AD) are still unknown. Here we develop a temporal model for these unobserved molecular changes with a manifold ...
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Article
Open AccessA novel systems biology approach to evaluate mouse models of late-onset Alzheimer’s disease
Late-onset Alzheimer’s disease (LOAD) is the most common form of dementia worldwide. To date, animal models of Alzheimer’s have focused on rare familial mutations, due to a lack of frank neuropathology from mo...
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Loss of ADAMTS19 causes progressive non-syndromic heart valve disease
Valvular heart disease is observed in approximately 2% of the general population1. Although the initial observation is often localized (for example, to the aortic or mitral valve), disease manifestations are regu...
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Open AccessGenetic perturbations of disease risk genes in mice capture transcriptomic signatures of late-onset Alzheimer’s disease
New genetic and genomic resources have identified multiple genetic risk factors for late-onset Alzheimer’s disease (LOAD) and characterized this common dementia at the molecular level. Experimental studies in ...
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Open AccessVariable outcomes of human heart attack recapitulated in genetically diverse mice
Clinical variation in patient responses to myocardial infarction (MI) has been difficult to model in laboratory animals. To assess the genetic basis of variation in outcomes after heart attack, we characterize...
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ROBO4 variants predispose individuals to bicuspid aortic valve and thoracic aortic aneurysm
Bicuspid aortic valve (BAV) is a common congenital heart defect (population incidence, 1–2%)1–3 that frequently presents with ascending aortic aneurysm (AscAA)4. BAV/AscAA shows autosomal dominant inheritance wit...
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Mutations in SGOL1 cause a novel cohesinopathy affecting heart and gut rhythm
Gregor Andelfinger and colleagues identify mutations in SGOL1 that cause a novel cohesinopathy characterized by chronic atrial and intestinal dysrhythmia, termed CAID syndrome. SGOL1 encodes a component of the co...
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Book
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Chapter
Introduction
This introductory chapter starts with presenting the background and aims as well as the objectives of the research problem. It also presents the structure and purpose of the present thesis.
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Chapter
Methodology and methods
The aim of this chapter is to outline the selected methodological and methodical research approach employed. This chapter provides the rationale for the methodology applied in this research project by position...
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Chapter
Discussion of results
This final chapter aims at evaluating the results of the research project in the context of the research questions and hypotheses. Chapter 4 presented the results. This chapter evaluates these results with a s...
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Chapter
Retail marketing, concepts and research model
The aim of this chapter is to present an overview of the essential terms and conceptual basics which are necessary for a comprehensive understanding of the research problem. This comprises the definition of re...
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Chapter
Results
The aim of this chapter is to present the findings and analyses of the primary data collection process. Chapters 2 and 3 outlined the research design covering the methods and approaches applied at each researc...
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Article
Open AccessComparative Analysis of Expressed Sequence Tag (EST) Libraries in the Seagrass Zostera marina Subjected to Temperature Stress
Global warming is associated with increasing stress and mortality on temperate seagrass beds, in particular during periods of high sea surface temperatures during summer months, adding to existing anthropogeni...
