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  1. Article

    Open Access

    The role of the cancer stem cell marker CD271 in DNA damage response and drug resistance of melanoma cells

    Several lines of evidence have suggested that stemness and acquired resistance to targeted inhibitors or chemotherapeutics are mechanistically linked. Here we observed high cell surface and total levels of ner...

    T Redmer, I Walz, B Klinger, S Khouja, Y Welte, R Schäfer, C Regenbrecht in Oncogenesis (2017)

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  2. Article

    Open Access

    Uncoupling of EGFR–RAS signaling and nuclear localization of YBX1 in colorectal cancer

    The transcription factor YBX1 can act as a mediator of signals transmitted via the EGFR–RAS–MAPK axis. YBX1 expression has been associated with tumor progression and prognosis in multiple types of cancer. Immu...

    F Roßner, C Gieseler, M Morkel, H-D Royer, M Rivera, H Bläker, M Dietel… in Oncogenesis (2016)

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  3. No Access

    Article

    Transgenic expression of oncogenic BRAF induces loss of stem cells in the mouse intestine, which is antagonized by β-catenin activity

    Colon cancer cells frequently carry mutations that activate the β-catenin and mitogen-activated protein kinase (MAPK) signaling cascades. Yet how oncogenic alterations interact to control cellular hierarchies ...

    P Riemer, A Sreekumar, S Reinke, R Rad, R Schäfer, C Sers, H Bläker… in Oncogene (2015)

  4. No Access

    Article

    Oncogenic HRAS suppresses clusterin expression through promoter hypermethylation

    Silencing of gene expression by methylation of CpG islands in regulatory elements is frequently observed in cancer. However, an influence of the most common oncogenic signalling pathways onto DNA methylation h...

    P Lund, K Weißhaupt, T Mikeska, D Jammas, X Chen, R-J Kuban, U Ungethüm… in Oncogene (2006)

  5. No Access

    Article

    The PI3K inhibitor LY294002 blocks drug export from resistant colon carcinoma cells overexpressing MRP1

    Multidrug resistance may be achieved by the activation of membrane transporters, detoxification, alterations in DNA repair or failure in apoptotic pathways. Recent data have suggested an involvement of mitogen...

    R Abdul-Ghani, V Serra, B Györffy, K Jürchott, A Solf, M Dietel, R Schäfer in Oncogene (2006)

  6. No Access

    Article

    Chromosomal assignment of three rat and human H-rev genes, putative tumor suppressors, down-regulated in malignantly HRAS-transformed cells

    C. Szpirer, J. Szpirer, M. Rivière, A. Hajnal, M. Kiess, B. Scharm… in Mammalian Genome (1996)

  7. No Access

    Article

    Human oncogenes

    The information published on human oncogenes up to the fall of 1983 is reviewed. Retroviral oncogenes, protooncogenes, and cellular transforming genes are compared. Transforming genes derived from the ras gene...

    K. Willecke, R. Schäfer in Human Genetics (1984)

  8. No Access

    Article

    Assignment of the gene for cytoplasmic glutamate-oxaloacetate transaminase to mouse chromosome 19 using Chinese hamster x mouse somatic cell hybrids

    Chinese hamster and mouse cytoplasmic glutamate-oxaloacetate transaminase (GOT-1, EC 2.6.1.1) were separated by isoelectric focusing of cell extracts on thin-layer polyacrylamide plates. The expression of mous.....

    R. Schäfer, J. Doehmer, I. Rademacher, K. Willecke in Somatic Cell Genetics (1980)

  9. No Access

    Article

    Häufigkeit und Wertung der epitheloidzelligen Granulome in der Milz bei Morbus Hodgkin

    Macroscopic and microscopic examination of 154 spleens from patients with lymphogranulomatosis revealed focal alterations in 71 (46%) specimens, 55 (=36%) of which showed typical Hodgkin granuloma while in 16 ...

    H. -M. Schneider, R. Schäfer, K. Hill in Klinische Wochenschrift (1977)