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  1. No Access

    Article

    Transgenic expression of oncogenic BRAF induces loss of stem cells in the mouse intestine, which is antagonized by β-catenin activity

    Colon cancer cells frequently carry mutations that activate the β-catenin and mitogen-activated protein kinase (MAPK) signaling cascades. Yet how oncogenic alterations interact to control cellular hierarchies ...

    P Riemer, A Sreekumar, S Reinke, R Rad, R Schäfer, C Sers, H Bläker… in Oncogene (2015)

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    Chapter

    Defeating Randomness – Targeted Integration as a Boost for Biotechnology

    Genetic modification of mammalian cells is a prerequisite for the production of recombinant proteins, virus like particles, and viruses. For most applications long-term stability of such modifications is neede...

    L. Gama-Norton, P. Riemer, U. Sandhu, K. Nehlsen, R. Schucht… in Cell Line Development (2009)