-
Article
Open AccessThe role of the cancer stem cell marker CD271 in DNA damage response and drug resistance of melanoma cells
Several lines of evidence have suggested that stemness and acquired resistance to targeted inhibitors or chemotherapeutics are mechanistically linked. Here we observed high cell surface and total levels of ner...
-
Article
ONE YEAR TREATMENT WITH ICF-1 OF CHILDREN WITH LARON SYNDROME (LS)
Having found that recombinant IGF-I acts in children after acute (Lancet “II: 1170, 1988), short term (Clin Endocr 36: 301, 1992) and long administration (Lancet 339: 1258, 1992), treatment on a long-term basi...
-
Article
LONG-TERM hGH TREATMENT OF SHORT PREPUBERTAL CHILDREN IMPROVES THEIR HEIGHT
Forty-six short children classified as familial short stature (FSS) or intrautcrinc growth retardation (1UGR) and normal GH reserve (≥ 10 ng/ml) were t recited with rhCH (Norditropin - Novo/Nordisk, 0.1 U/kg/d...
-
Article
Growth hormone therapy in normal short children induces a transitory decrease in plasma growth hormone releasing hormone levels and in human growth hormone responsiveness to exogenous growth hormone releasing hormone
A three-month study of the effect of growth hormone (hGH) therapy (0.1 U/kg/day sc) on plasma levels of GH releasing hormone (GHRH), somatostatin and insulin-like growth factor I (IGF-I) and on the hGH respons...
-
Article
42 SERUM GROWTH HORMONE BINDING PROTEIN (GH-BP) IN PRE-PUBERTAL CHILDREN IS CORRELATED WITH HEIGHT
Recently serum GH-BP has been shown to have identical N-terminal amino acid sequence as the tissue hGH receptor. Serum hGH levels and the specific binding activity of GH-BP (expressed as % of GH-BP activity of...
-
Article
108 IGF-BINDING TO READ BLOOD CELLS OF SIIORT AND TALL BOYS. COMPARIOSON WITH CH-BINDING PROTEIN LEVELS
Binding of 125I-ICF-I to red blood cells (RBC) was determined in 12 prepubertal boys aged 7-9 yrs, 6 with short stature ( ≤ 2 SD height) and 6 with tall stature ( ≥ 2 SD height). Concomitantly blood hCH, IGF-I an...
