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  1. No Access

    Chapter

    Inhibition of Cytochrome P450 Enzymes by Nitric Oxide

    Inflammatory Stimulation of the liver causes significant alterations in liver cell metabolism. Recent experimental studies indicate that induction of nitric oxide (NO) biosynthesis may play a major role in the...

    J. Stadler, W. A. Schmalix, J. Doehmer in Biological Reactive Intermediates V (1996)

  2. No Access

    Chapter and Conference Paper

    Use of Recombinant Cells in Metabolic and Mechanistic Studies

    Gene technology had an extensive impact on the understanding of xenobiotics metabolism over the last decade. This includes detection of novel cytochromes P450 and conjugating enzymes, elucidation of the chromo...

    W. A. Schmalix, J. Doehmer in Toxicology in Transition (1995)

  3. No Access

    Chapter and Conference Paper

    Strategies for the Use of Single Cytochrome P450 Enzymes in Drug Research and Future Prospects

    Analytical tools have always played an important role for the understanding of complex biological systems such as drug metabolism. Technology is required to develop analytical tools. In this context, cell cult...

    J. Doehmer in Assessment of the Use of Single Cytochrome P450 Enzymes in Drug Research (1994)

  4. No Access

    Chapter

    Cytochromes P450 in Genetically Engineered Cell Cultures: The Gene Technological Approach

    Molecular cloning of genes encoding cytochromes P450 followed by heterologous expression in various systems is being successfully applied in multi-faceted studies of cytochromes P450. The application of modern...

    J. Doehmer, H. Greim in Cytochrome P450 (1993)

  5. No Access

    Article

    Uniform response of c-raf expression to differentiation induction and inhibition of proliferation in a rat rhabdomyosarcoma cell line

    The clonal rat rhabdomyosarcoma cell line BA-HAN-1C is composed of proliferating mononuclear cells, some of which spontaneously fuse to terminally differentiated myotube-like giant cells. Both the induction of...

    U. Ramp, C. D. Gerharz, J. Doehmer, O. Oster, H. E. Gabbert in Virchows Archiv B (1990)

  6. No Access

    Chapter and Conference Paper

    Introduction of Cytochrome P-450 Genes into V79 Chinese Hamster Cells to Generate New Mutagenicity Test Systems

    Usually, cultivated cells have poor capabilities to metabolize promutagens and procarcinogens. This is particularly true for cells that grow fast and have a high cloning efficiency, as is the case with V79 Chi...

    J. Doehmer, S. Dogra, M. Edigkaufer… in Biological Monitoring of Exposure and the … (1989)

  7. No Access

    Article

    Assignment of the gene for cytoplasmic glutamate-oxaloacetate transaminase to mouse chromosome 19 using Chinese hamster x mouse somatic cell hybrids

    Chinese hamster and mouse cytoplasmic glutamate-oxaloacetate transaminase (GOT-1, EC 2.6.1.1) were separated by isoelectric focusing of cell extracts on thin-layer polyacrylamide plates. The expression of mous.....

    R. Schäfer, J. Doehmer, I. Rademacher, K. Willecke in Somatic Cell Genetics (1980)

  8. No Access

    Chapter and Conference Paper

    Genetic Transmission of Moloney Leukemia Virus: Map** of the Chromosomal Integration Site

    Mice genetically transmitting the exogenous Moloney leukemia virus (Balb/Mo) have been previously derived. These animals carried one copy of Moloney virus DNA (M-MuLV) in their germ line and transmitted the vi...

    J. Doehmer, M. Breindl, K. Willecke, R. Jaenisch in Modern Trends in Human Leukemia III (1979)