-
Article
Rat Chromosome 1: Regional localization of seven genes (Slc9a3, Srd5a1, Esr, Tcp1, Grik5, Tnnt3, Jak2) and anchoring of the genetic linkage map to the cytogenetic map
Seven genes were regionally localized on rat Chromosome (Chr) 1, from 1p11 to 1q42, and two of these genes were also included in a linkage map. This map** work integrates the genetic linkage map and the cyto...
-
Article
FISH map** of three ammonia metabolism genes (Glul, Cps1, Glud1) in rat, and the chromosomal localization of GLUL in human and Cps1 in mouse
-
Article
Map** of the ribonucleotide reductase genes (Rrm1, Rrm2) in the rat
-
Article
Chromosomal assignment of three rat and human H-rev genes, putative tumor suppressors, down-regulated in malignantly HRAS-transformed cells
-
Article
Chromosomal map** of the rat Slc4a family of anion exchanger genes, Ael, Ae2, and Ae3
-
Article
Regional localization of the rat genes encoding the cAMP-specific phosphodiesterases 3 (Pde4d) and 4 (Pde4b) and the tyrosinase-related protein 1 (Tyrp1)
-
Article
A genetic linkage map of the rat derived from recombinant inbred strains
We have constructed a genetic linkage map in the rat by analyzing the strain distribution patterns of 500 genetic markers in a large set of recombinant inbred strains derived from the spontaneously hypertensiv...
-
Article
Map** of the calcium-sensing receptor gene (CASR) to human Chromosome 3q13.3-21 by fluorescence in situ hybridization, and localization to rat Chromosome 11 and mouse Chromosome 16
The calcium-sensing receptor (CASR), a member of the G-protein coupled receptor family, is expressed in both parathyroid and kidney, and aids these organs in sensing extracellular calcium levels. Inactivating ...
-
Article
Use of simple sequence length polymorphisms for genetic characterization of rat inbred strains
Genetic monitoring is an essential component of colony management and for the rat has been accomplished primarily by using immunological and biochemical markers. Here, we report that simple sequence length pol...
-
Article
A genetic map of microsatellite markers on rat Chromosome 7
Nine microsatellite loci were mapped to rat Chromosome (Chr) 7 by genetic linkage and somatic cell hybrid analysis. These loci include the gene encoding a member of the IID sub-family of cytochrome P450 (Cyp2d), ...
-
Article
Map** of the gene for rat protein phosphatase 1α (Ppp1ca) to Chromosome 1
-
Article
Chromosomal assignment of 11 loci in the rat by mouse-rat somatic hybrids and linkage
Eleven rat genes have been assigned to rat chromosomes by use of mouse × rat somatic hybrids and/or use of linkage to known chromosome markers. Among them, the genes for the inducible nitric oxide synthase (Nos2)...
-
Article
Assignment of rat Jun family genes to Chromosome 19 (Junb), Chromosome 5q31–33 (Jun), and Chromosome 16 (Jund)
By means of somatic cell hybrids segregating rat chromosomes, we determined the chromosome localization of three rat genes of the Jun family: Jumb (Chr 19), Jun (=c-Jun) (Chr 5) and Jund (Chr 16). The Jun gene wa...
-
Article
Chromosomal assignment of four genes encoding Na/H exchanger isoforms in human and rat
The plasma membrane Na/H exchanger plays an essential role in regulating intracellular pH and Na+ concentration and has been implicated in several pathophysiological conditions, including essential hypertension a...
-
Article
Major chromatin changes accompany extinction of α-fetoprotein gene in hepatoma × fibroblast hybrids
The sensitivity of the α-fetoprotein (AFP) gene to digestion by the enzyme DNaseI, and the presence of hypersensitive sites in the 5′ region of this gene, were examined in hepatoma × fibroblast hybrid cells th...
-
Article
Genes for C4b-binding protein α- and β-chains (C4BPA andC4BPB) are located on chromosome 1, band 1q32, in humans and on chromosome 13 in rats
C4b-binding protein is involved in the regulation of the complement system. It is a multimeric protein composed of seven identical α-chains and a single copy of a unique β-chain. The latter was identified only...
-
Chapter and Conference Paper
Expression and Chromosomal Assignment of a Novel Protein-Tyrosine Kinase Gene Related to the Insulin Receptor Family
There is growing evidence in recent literature for the involvement of protein-tyrosine phosphorylation in the early events of leukocyte activation. Interleukin-3 (IL-3), a growth factor essential for the growt...
-
Chapter
Somatic Cell Genetic Analysis of Growth Control
These last years, a growing number of altered genes have been implicated in neoplastic development. These genes, in their normal guise, are supposed to be involved in the control of cell growth. Two seemingly ...
-
Article
Assignment of gene for coagulation factor V to chromosome 1 in man and to chromosome 13 in rat
Two different factor V cDNA fragments were used as hydridization probes in the chromosomal assignment of the human and rat factor V genes. A 1.6-kb EcoRI fragment was used as a hybridization probe to analyze a...
-
Chapter and Conference Paper
The Rat Gene Map
Rat genetics is much less developed than mouse (or human) genetics. Since the rat is used as an experimental animal in several fields, such as cancer research, this lack of genetic information is often frustra...