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Article
Previous fracture and subsequent fracture risk: a meta-analysis to update FRAX
A large international meta-analysis using primary data from 64 cohorts has quantified the increased risk of fracture associated with a previous history of fracture for future use in FRAX.
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Article
Update of the fracture risk prediction tool FRAX: a systematic review of potential cohorts and analysis plan
We describe the collection of cohorts together with the analysis plan for an update of the fracture risk prediction tool FRAX with respect to current and novel risk factors. The resource comprises 2,138,428 p...
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Article
Klinefelter Bone Microarchitecture Evolution with Testosterone Replacement Therapy
Klinefelter Syndrome (KS) patients, defined by a 47 XXY karyotype, have increased risk of fragility fractures. We have assessed bone microarchitecture by high resolution peripheral quantitative CT (HR-pQCT) at...
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Article
Open AccessIs it time to consider population screening for fracture risk in postmenopausal women? A position paper from the International Osteoporosis Foundation Epidemiology/Quality of Life Working Group
The IOF Epidemiology and Quality of Life Working Group has reviewed the potential role of population screening for high hip fracture risk against well-established criteria. The report concludes that such an ap...
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Article
Open AccessThe clinical application of high-resolution peripheral computed tomography (HR-pQCT) in adults: state of the art and future directions
High-resolution peripheral computed tomography (HR-pQCT) was developed to image bone microarchitecture in vivo at peripheral skeletal sites. Since the introduction of HR-pQCT in 2005, clinical research to gain...
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Article
Biochemical bone turnover markers in hormonal disorders in adults: a narrative review
Hormonal disorders are often associated with abnormal levels of bone turnover markers (BTMs). N-terminal propeptide of type I procollagen (PINP) and serum C-terminal cross-linking telopeptide of type I collage...
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Article
Use of CTX-I and PINP as bone turnover markers: National Bone Health Alliance recommendations to standardize sample handling and patient preparation to reduce pre-analytical variability
The National Bone Health Alliance (NBHA) recommends standardized sample handling and patient preparation for C-terminal telopeptide of type I collagen (CTX-I) and N-terminal propeptide of type I procollagen (P...
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Article
Has sclerostin a true endocrine metabolic action complementary to osteocalcin in older men?
The reported association between sclerostin and diabetes mellitus or abdominal fat may be biased by body size and bone mass. In older men, the association between serum sclerostin levels and metabolic syndrome...
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Article
Numerical analysis of a waste heat recovery process with account of condensation of steam from flue gases
This paper presents modelling of the process of condensation of steam contained in flue gases in systems for waste heat recovery from flue gases. A one-dimensional, non-stationary mathematical model of a heat ...
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Article
Oxytocin and bone status in men: analysis of the MINOS cohort
Oxytocin, a neurohypophysial hormone, regulates bone metabolism in animal studies and postmenopausal women. In men, oxytocin is not associated with bone mineral density, bone turnover markers, or prevalent fra...
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Article
Family resemblance of bone turnover rate in mothers and daughters—the MODAM study
We studied bone turnover markers (BTM) and bone microarchitecture (using high-resolution peripheral quantitative computed tomography (HR-pQCT)) in 171 postmenopausal women and their 210 premenopausal daughters...
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Article
Standardising the descriptive epidemiology of osteoporosis: recommendations from the Epidemiology and Quality of Life Working Group of IOF
The Committee of Scientific Advisors of International Osteoporosis Foundation (IOF) recommends that papers describing the descriptive epidemiology of osteoporosis using bone mineral density (BMD) at the femora...
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Article
Impaired trabecular and cortical microarchitecture in daughters of women with osteoporotic fracture: the MODAM study
We investigated the familial resemblance of bone microarchitecture parameters between postmenopausal mothers with fragility fracture and their premenopausal daughters using high-resolution peripheral quantitat...
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Article
Severity of aortic calcification is positively associated with vertebral fracture in older men—a densitometry study in the STRAMBO cohort
In older men, severe abdominal aortic calcification and vertebral fracture (both assessed using dual-energy X-ray absorptiometry) were positively associated after adjustment for confounders including bone mine...
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Article
Sarcopenia and its relationship with bone mineral density in middle-aged and elderly European men
The aim of this study was to determine the relationship between reduced muscle mass (sarcopenia) and areal bone mineral density (BMDa) in middle-aged and elderly community-dwelling European men. Men with sarcopen...
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Article
Poor bone microarchitecture in older men with impaired physical performance—the STRAMBO study
In 810 men ≥60 years, poor physical performance of lower limbs was associated with lower areal bone mineral density (aBMD) of total hip and poor bone microarchitecture at the distal tibia (assessed by HR-pQCT)...
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Article
Poor Trabecular Microarchitecture at the Distal Radius in Older Men with Increased Concentration of High-Sensitivity C-Reactive Protein—The Strambo Study
Low-grade inflammation, assessed by serum high-sensitivity C-reactive protein (hsCRP) concentration, is associated with higher fracture risk irrespective of areal bone mineral density (aBMD). We assessed the a...
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Article
Poor Trabecular Microarchitecture in Male Current Smokers: The Cross-Sectional STRAMBO Study
Current smoking (but not past smoking) is associated with higher risk of fracture independent of areal bone mineral density (aBMD); however, the pathophysiologic mechanism underlying this association is not cl...
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Article
Risk factors for peripheral fractures vary by age in older men—the prospective MINOS study
Identification of older men at high risk of peripheral fracture can be improved by assessing prevalent fractures (men aged ≤65), history of falls (men aged >65), bone width, and aortic calcifications.
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Article
Thinking inside and outside the envelopes of bone
Bone modeling and remodeling is the final common pathway expressing all genetic and environmental factors that influence the attainment and maintenance of bone’s material and structural strength. Modeling and ...
