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Family resemblance of bone turnover rate in mothers and daughters—the MODAM study

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Abstract

Summary

We studied bone turnover markers (BTM) and bone microarchitecture (using high-resolution peripheral quantitative computed tomography (HR-pQCT)) in 171 postmenopausal women and their 210 premenopausal daughters. BTM levels correlated positively between mothers and daughters. The mother-daughter pairs with high BTM levels had lower cortical density than those with low BTM levels.

Introduction

We assessed the correlation of serum bone turnover markers (BTM) between postmenopausal mothers and their premenopausal daughters as well as possible determinants of this association and its impact on resemblance of bone microarchitecture between mothers and their daughters.

Methods

Cross-sectional analysis was performed in 171 untreated postmenopausal mothers (54 sustained fragility fractures) and their 210 premenopausal daughters. Intact N-terminal propeptide of type I collagen (PINP) and β-isomerized C-terminal crosslinking telopeptide of type I collagen (CTX-I) were measured in the fasting status. Bone microarchitecture was assessed using HR-pQCT.

Results

After adjustment for age, weight, lifestyle factors, hormones, and mother’s fracture status, BTM levels correlated positively between mothers and daughters (Intraclass Correlation Coefficient = 0.22–0.27, p <0.005). Average BTM levels were ∼0.6 SD higher among daughters of mothers in the highest BTM quartile vs. the ones in the lowest BTM quartile. The variability of BTM levels explained ≤10 and ≤14 % of variability of bone microarchitecture in the daughters and mothers, respectively. Cortical density was lower by 2.3–2.9 % (0.6 SD, p <0.05 to <0.005) in the daughters from the mother-daughter pairs with high BTM levels (defined by generation-specific quartiles) than in the daughters from the pairs with low BTM levels. Corresponding differences for the mothers were 4.5–4.8 % (0.5 SD, p <0.05 to <0.01).

Conclusion

BTM levels correlated between postmenopausal mothers and their premenopausal daughters after adjustment for age, weight, mother’s fracture status, lifestyle, and hormonal factors. Family resemblance of BTM levels may contribute to family resemblance of some bone microarchitectural parameters, especially of cortical density.

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Acknowledgments

The authors thank Dr. Bruno Claustrat for the measurements of sex steroid hormones. The authors also thank Olivier Borel and Cindy Bertholon for the laboratory analysis. Also, we thank Annick Bourgeaud, Sylviane Ailloud, and Yvonne Varillon for the excellent technical assistance.

Conflicts of interest

Hoda Nagy, Roland Chapurlat, Elisabeth Sornay-Rendu, Stéphanie Boutroy, and Pawel Szulc declare that they have no conflicts of interest.

Dr. Nagy’s efforts were supported by the fellowships from the Egyptian Government and from the Société Française de Rhumatologie.

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Authors and Affiliations

  1. INSERM UMR 1033, Université de Lyon, Hôpital Édouard Herriot, Pavillon F, Place d’Arsonval, 69437, Lyon, France

    H. Nagy, R. Chapurlat, E. Sornay-Rendu, S. Boutroy & P. Szulc

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  1. H. Nagy
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Correspondence to P. Szulc.

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Nagy, H., Chapurlat, R., Sornay-Rendu, E. et al. Family resemblance of bone turnover rate in mothers and daughters—the MODAM study. Osteoporos Int 26, 921–930 (2015). https://doi.org/10.1007/s00198-014-2974-0

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