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Article
Open AccessAuthor Correction: An Autogenously Regulated Expression System for Gene Therapeutic Ocular Applications
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
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Article
Open AccessAn Autogenously Regulated Expression System for Gene Therapeutic Ocular Applications
The future of treating inherited and acquired genetic diseases will be defined by our ability to introduce transgenes into cells and restore normal physiology. Here we describe an autogenous transgene regulato...
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Article
Crystal structure of the λ repressor and a model for pairwise cooperative operator binding
A crystal structure of the intact, dimeric phage λ cI repressor bound to a DNA operator site reveals an unusual architecture allowing the repressor to adopt a conformation that facilitates cooperative binding ...
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Article
Open AccessPrevalence of the EH1 Groucho interaction motif in the metazoan Fox family of transcriptional regulators
The Fox gene family comprises a large and functionally diverse group of forkhead-related transcriptional regulators, many of which are essential for metazoan embryogenesis and physiology. Defining conserved funct...
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Article
A closer view of the conformation of the Lac repressor bound to operator
Crystal structures of the Lac repressor, with and without isopropylthiogalactoside (IPTG), and the repressor bound to operator have provided a model for how the binding of the inducer reduces the affinity of t...
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Article
The operator-binding domain of λ repressor: structure and DNA recognition
The structure of the operator-binding domain of the λ repressor has been determined at 3.2 Å resolution. This domain contains an extended N-terminal arm and five α-helices. Model-building studies of the repres...
