-
Article
Evaluation of Methylotrophic Yeast Ogataea thermomethanolica TBRC 656 as a Heterologous Host for Production of an Animal Vaccine Candidate
Multiple yeast strains have been developed into versatile heterologous protein expression platforms. Earlier works showed that Ogataea thermomethanolica TBRC 656 (OT), a thermotolerant methylotrophic yeast, can e...
-
Article
Open AccessBiochemical and functional characterization of Plasmodium falciparum GTP cyclohydrolase I
Antifolates are currently in clinical use for malaria preventive therapy and treatment. The drugs kill the parasites by targeting the enzymes in the de novo folate pathway. The use of antifolates has now been lim...
-
Article
ATP-independent reversal of a membrane protein aggregate by a chloroplast SRP subunit
Membrane proteins require chaperones to keep them soluble and translocation-competent. New studies have identified a chloroplast signal recognition particle, cpSRP43, as a highly specific, ATP-independent chap...
-
Article
Crystal structure of the λ repressor and a model for pairwise cooperative operator binding
A crystal structure of the intact, dimeric phage λ cI repressor bound to a DNA operator site reveals an unusual architecture allowing the repressor to adopt a conformation that facilitates cooperative binding ...