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  1. Article

    Open Access

    Anti-tumor effects of an ID antagonist with no observed acquired resistance

    ID proteins are helix-loop-helix (HLH) transcriptional regulators frequently overexpressed in cancer. ID proteins inhibit basic-HLH transcription factors often blocking differentiation and sustaining prolifera...

    Paulina M. Wojnarowicz, Marta Garcia Escolano, Yun-Han Huang… in npj Breast Cancer (2021)

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  2. Article

    Open Access

    Prevalence of the EH1 Groucho interaction motif in the metazoan Fox family of transcriptional regulators

    The Fox gene family comprises a large and functionally diverse group of forkhead-related transcriptional regulators, many of which are essential for metazoan embryogenesis and physiology. Defining conserved funct...

    Sergey Yaklichkin, Alexander Vekker, Steven Stayrook, Mitchell Lewis… in BMC Genomics (2007)

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  3. No Access

    Chapter

    Transcriptional Repression in Spemann’s Organizer and the Formation of Dorsal Mesoderm

    The early events of vertebrate embryogenesis establish the three germ layers, endoderm, mesoderm and neuroectoderm, and interactions between these lineages, both before and during gastrulation, determine the b...

    Sergey Yaklichkin, Aaron B. Steiner, Daniel S. Kessler in The Vertebrate Organizer (2004)