62 Result(s)
within
Ming Lei
Life Sciences
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Article
Open AccessNoncoding RNAs in atherosclerosis: regulation and therapeutic potential
Atherosclerosis, a chronic disease of arteries, results in high mortality worldwide as the leading cause of cardiovascular disease. The development of clinically relevant atherosclerosis involves the dysfuncti...
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Open AccessInsight into telomere regulation: road to discovery and intervention in plasma drug-protein targets
Telomere length is a critical metric linked to aging, health, and disease. Currently, the exploration of target proteins related to telomere length is usually limited to the context of aging and specific disea...
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The Effect of Rheumatoid Arthritis on Features Associated with Sarcopenia: A Mendelian Randomization Study
Previous epidemiological evidence suggests rheumatoid arthritis is associated with sarcopenia-related features. However, most of the current evidence is from cross-sectional studies, and the causal link of thi...
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Open AccessMolecular mechanism and therapeutic potential of HDAC9 in intervertebral disc degeneration
Intervertebral disc degeneration (IVDD) is the major cause of low-back pain. Histone deacetylase 9 (HDAC9) was dramatically decreased in the degenerative nucleus pulposus (NP) samples of patients with interver...
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Open AccessCorrection: UPLC–ESI–QTOF–MS profiling, antioxidant, antidiabetic, antibacterial, anti-inflammatory, antiproliferative activities and in silico molecular docking analysis of Barleria strigosa
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Open AccessHuman myofibroblasts increase the arrhythmogenic potential of human induced pluripotent stem cell-derived cardiomyocytes
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have the potential to remuscularize infarcted hearts but their arrhythmogenicity remains an obstacle to safe transplantation. Myofibroblas...
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Open AccessUPLC–ESI–QTOF–MS profiling, antioxidant, antidiabetic, antibacterial, anti-inflammatory, antiproliferative activities and in silico molecular docking analysis of Barleria strigosa
This study investigated the in vitro antidiabetic, antioxidant, antibacterial, anti-inflammatory and antiproliferative effects of B. strigosa hydrophilic (BSTR) and lipophilic (LSB) leaves extracts. The phytochem...
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Open AccessAdvancing equity through strengthening research on health and well-being of Asian American, Native Hawaiian, and Pacific Islander
The National Institutes of Health’s Asian American, Native Hawaiian and Pacific Islander Health Scientific Interest Group (NIH AANHPI-HSIG) provides a viewpoint on develo** approaches to enhance research on ...
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Bioengineered models of Parkinson’s disease using patient-derived dopaminergic neurons exhibit distinct biological profiles in a 3D microenvironment
Three-dimensional (3D) in vitro culture systems using human induced pluripotent stem cells (hiPSCs) are useful tools to model neurodegenerative disease biology in physiologically relevant microenvironments. Th...
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Nutrient Uptake and Plant Growth Under the Influence of Toxic Elements
Contamination of plants with toxic elements (TEs) is a renowned environmental issue worldwide. The rapid increase in population and high food demand give rise to several pollutants that finally contaminate the...
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Open AccessZipper head mechanism of telomere synthesis by human telomerase
Telomerase, a multi-subunit ribonucleoprotein complex, is a unique reverse transcriptase that catalyzes the processive addition of a repeat sequence to extend the telomere end using a short fragment of its own...
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Structural insights into transcriptional regulation of human RNA polymerase III
RNA polymerase III (Pol III) synthesizes structured, essential small RNAs, such as transfer RNA, 5S ribosomal RNA and U6 small nuclear RNA. Pol III, the largest nuclear RNA polymerase, is composed of a conserv...
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Open AccessCo-activation of Akt, Nrf2, and NF-κB signals under UPRER in torpid Myotis ricketti bats for survival
Bats hibernate to survive stressful conditions. Examination of whole cell and mitochondrial proteomes of the liver of Myotis ricketti revealed that torpid bats had endoplasmic reticulum unfolded protein response ...
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Open AccessCryo-EM structures of human calcium homeostasis modulator 5
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Structural insights into telomere protection and homeostasis regulation by yeast CST complex
Budding yeast Cdc13–Stn1–Ten1 (CST) complex plays an essential role in telomere protection and maintenance. Despite extensive studies, only structural information of individual domains of CST is available; the...
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Effects of Spo0A on Clostridium acetobutylicum with an emphasis on biofilm formation
Clostridium acetobutylicum is a well-known strain for biofuel production. In previous work, it was found that this strain formed biofilm readily during fermentation processes. Biofilm formation could protect cell...
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Open AccessNT5DC2 promotes tumor cell proliferation by stabilizing EGFR in hepatocellular carcinoma
Most hepatocellular carcinoma (HCC) patients are diagnosed at an advanced stage; however, the effect of systemic therapy on advanced HCC remains undetermined. Therefore, new treatment targets must be identifie...
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Structural basis of the crosstalk between histone H2B monoubiquitination and H3 lysine 79 methylation on nucleosome
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Telomeric TERB1–TRF1 interaction is crucial for male meiosis
Disrupting the interaction between telomere protein TRF1 with meiosis-specific protein TERB1 impairs the pairing of X and Y chromosomes via their telomere-adjacent pseudoautosomal regions in pachytene, leading...
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Structural and functional analyses of the mammalian TIN2-TPP1-TRF2 telomeric complex
Telomeres are nucleoprotein complexes that play essential roles in protecting chromosome ends. Mammalian telomeres consist of repetitive DNA sequences bound by the shelterin complex. In this complex, the POT1-...
