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Article
Open AccessNT5DC2 promotes tumor cell proliferation by stabilizing EGFR in hepatocellular carcinoma
Most hepatocellular carcinoma (HCC) patients are diagnosed at an advanced stage; however, the effect of systemic therapy on advanced HCC remains undetermined. Therefore, new treatment targets must be identifie...
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Article
Kinematics for a six-axis EDM machine by screw theory and its application in feedrate planning in EDM for shrouded blisks
In multi-axis electrical discharging machining (EDM), to maintain a stable discharging gap, a gap width controller regulates the feedrate of a tool electrode with respect to a workpiece. However, in the existi...
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Article
HMGB1 correlates with angiogenesis and poor prognosis of perihilar cholangiocarcinoma via elevating VEGFR2 of vessel endothelium
Perihilar cholangiocarcinoma (PHCCA) is the most common type of cholangiocarcinoma with low resection rate and high morbidity. The study of PHCCA biomarkers made progresses slowly compared with intrahepatic ch...
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Article
A look-ahead transition algorithm and jump motion planning in multi-axis EDM for shrouded blisks
Shrouded blisks play a vital role in aero and rocket engines. Multi-axis EDM is regarded as the most commonly used manufacturing method for shrouded blisks. For a linear jump path, the jump motion only needs t...
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Article
A look-ahead transition algorithm for jump motions with short line segments in EDM
Most electrical discharge machining (EDM) machines provide only linear or circular interpolations. To machine a workpiece with a complex geometry, a large number of line segments in terms of G01 codes are used...
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Article
Open AccessPhospho-selective mechanisms of arrestin conformations and functions revealed by unnatural amino acid incorporation and 19F-NMR
Specific arrestin conformations are coupled to distinct downstream effectors, which underlie the functions of many G-protein-coupled receptors (GPCRs). Here, using unnatural amino acid incorporation and fluori...
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Article
Open AccessThe catalytic role of the M2 metal ion in PP2Cα
PP2C family phosphatases (the type 2C family of protein phosphatases; or metal-dependent phosphatase, PPM) constitute an important class of signaling enzymes that regulate many fundamental life activities. All...
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Article
Hepatoma-derived growth factor: a novel prognostic biomarker in intrahepatic cholangiocarcinoma
Hepatoma-derived growth factor (HDGF) is an acidic heparin-binding protein involved in tumor progression and poor prognosis of kinds of cancers. Aimed at investigating the functions of HDGF in intrahepatic cho...
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Article
Open AccessCadmium is a potent inhibitor of PPM phosphatases and targets the M1 binding site
The heavy metal cadmium is a non-degradable pollutant. By screening the effects of a panel of metal ions on the phosphatase activity, we unexpectedly identified cadmium as a potent inhibitor of PPM1A and PPM1G...
