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  1. Article

    Open Access

    Human myofibroblasts increase the arrhythmogenic potential of human induced pluripotent stem cell-derived cardiomyocytes

    Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have the potential to remuscularize infarcted hearts but their arrhythmogenicity remains an obstacle to safe transplantation. Myofibroblas...

    Robert D. Johnson, Ming Lei, John H. McVey… in Cellular and Molecular Life Sciences (2023)

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  2. Article

    Open Access

    The P2X7receptor is a candidate product of murine and human lupus susceptibility loci: a hypothesis and comparison of murine allelic products

    Systemic lupus erythematosus and its murine equivalent, modelled in the New Zealand Black and New Zealand White (NZB × NZW)F1 hybrid strain, are polygenic inflammatory diseases, probably reflecting an autoimmune ...

    James I Elliott, John H McVey, Christopher F Higgins in Arthritis Research & Therapy (2005)

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  3. No Access

    Article

    Bleeding due to disruption of a cargo-specific ER-to-Golgi transport complex

    Mutations in LMAN1 (also called ERGIC-53) result in combined deficiency of factor V and factor VIII (F5F8D), an autosomal recessive bleeding disorder characterized by coordinate reduction of both clotting protein...

    Bin Zhang, Michael A Cunningham, William C Nichols, John A Bernat… in Nature Genetics (2003)

  4. No Access

    Protocol

    Molecular Analysis in Factor XI Deficiency

    Factor XI (FXI) is the zymogen precursor of an active serine protease that participates in the contact phase of coagulation. Synthesized in the liver, it circulates in the plasma in a noncovalent complex with ...

    Karen M. Johnson, John H. McVey in Hemostasis and Thrombosis Protocols (1999)

  5. No Access

    Article

    Characterization of a recent retroposon insertion on mouse Chromosome 2 and localization of the cognate parental gene to Chromosome 11

    The genomic sequence on mouse Chromosome (Chr) 2 corresponding to a previously identified novel cDNA has been characterized. The genomic organization of this locus, adjacent to the beta 2 microglobulin gene, h...

    Donald B. Palmer, John H. McVey, Reshma Purohit, Jean Picard… in Mammalian Genome (1998)

  6. No Access

    Chapter

    Efficient Gene Transfer into Human Umbilical Vein Endothelial Cells Allows Functional Analysis of the Human Tissue Factor Gene Promoter

    Tissue factor (TF) is a cellular receptor and cofactor for factor VII/VIIa which inititates the blood coagulation cascade. We have investigated the role of 5′-flanking DNA sequences in regulating the expressio...

    Amit C. Nathwani, Karen M. Gale, Kieran D. Pemberton… in Vascular Endothelium (1996)

  7. No Access

    Protocol

    Staden Plus

    The Staden-Plus software is an old menu-driven version of Rodger Staden’s software for manipulation of DNA and protein sequences that will run on an IBM compatible PC. This program is of use to those workers w...

    John H. McVey in Computer Analysis of Sequence Data (1994)