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  1. No Access

    Article

    Bioengineered models of Parkinson’s disease using patient-derived dopaminergic neurons exhibit distinct biological profiles in a 3D microenvironment

    Three-dimensional (3D) in vitro culture systems using human induced pluripotent stem cells (hiPSCs) are useful tools to model neurodegenerative disease biology in physiologically relevant microenvironments. Th...

    Nicholas J. Fiore, Yosif M. Ganat, Kapil Devkota… in Cellular and Molecular Life Sciences (2022)

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    Article

    Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease

    A new strategy for derivation of human midbrain dopamine neurons from pluripotent cells was developed; transplantation of the neurons in mice, rats and parkinsonian monkeys show they are a promising source of ...

    Sonja Kriks, Jae-Won Shim, **ghua Piao, Yosif M. Ganat, Dustin R. Wakeman… in Nature (2011)

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    Article

    Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs

    Familial dysautonomia is a rare and fatal peripheral neuropathy caused by a mutation in the gene IKBKAP that encodes a protein involved in transcriptional elongation. Lee et al. report the derivation of patient-s...

    Gabsang Lee, Eirini P. Papapetrou, Hyesoo Kim, Stuart M. Chambers… in Nature (2009)