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Article
Open AccessVitamin D opposes multilineage cell differentiation induced by Notch inhibition and BMP4 pathway activation in human colon organoids
Understanding the mechanisms involved in colonic epithelial differentiation is key to unraveling the alterations causing inflammatory conditions and cancer. Organoid cultures provide an unique tool to address ...
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Article
Open AccessVitamin D and Wnt3A have additive and partially overlap** modulatory effects on gene expression and phenotype in human colon fibroblasts
The Wnt/β-catenin signalling pathway is essential for intestinal epithelium homeostasis, but its aberrant activation is a hallmark of colorectal cancer (CRC). Several studies indicate that the bioactive vitami...
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Article
Open AccessEndothelial cell activation on 3D-matrices derived from PDGF-BB-stimulated fibroblasts is mediated by Snail1
Carcinomas, such as colon cancer, initiate their invasion by rescuing the innate plasticity of both epithelial cells and stromal cells. Although Snail is a transcriptional factor involved in the Epithelial-Mes...
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Article
Open AccessDifferential distribution and enrichment of non-coding RNAs in exosomes from normal and Cancer-associated fibroblasts in colorectal cancer
Exosome production from cancer-associated fibroblasts seems to be an important driver of tumor progression. We report the first in-depth biotype characterization of ncRNAs, analyzed by Next Generation Sequenci...
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Chapter
Wnt Pathway at a Glance: From the Deep of the Crypts to the Current Ways of Targeting
Wnt/β-catenin signalling pathway is crucial for the formation of many tissues and organs during development. In recent years, this pathway has also been found to regulate the biology of stem cells in the intes...
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Chapter
Mechanisms of Resistance to Vitamin D Action in Human Cancer Cells
Initial clinical trials in cancer patients with vitamin D compounds have shown acceptable toxicity but low activity. A number of mechanisms responsible for resistance to their action in cancer cells have been ...
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Article
The transcription factor SNAIL represses vitamin D receptor expression and responsiveness in human colon cancer
Several non-hypercalcemic analogs of 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) show antitumor activity in a subset of cancer patients. High vitamin D receptor (VDR) expression, which is associated with good prognos...
