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  1. Article

    Open Access

    PGC-1alpha levels correlate with survival in patients with stage III NSCLC and may define a new biomarker to metabolism-targeted therapy

    Lung cancer remains the leading cause of cancer-related death worldwide, with one-third diagnosed with locally advanced (stage III) disease. Preoperative induction chemo-radiotherapy is key for the treatment o...

    Alberto Cruz-Bermúdez, Ramiro J. Vicente-Blanco… in Scientific Reports (2017)

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  2. No Access

    Article

    The Wnt antagonist DICKKOPF-1 gene is a downstream target of β-catenin/TCF and is downregulated in human colon cancer

    Wnt glycoproteins regulate homeostasis and development by binding to membrane Frizzled-LRP5/6 receptor complexes. Wnt signaling includes a canonical pathway involving cytosolic β-catenin stabilization, nuclear tr...

    José Manuel González-Sancho, Oscar Aguilera, José Miguel García… in Oncogene (2005)

  3. No Access

    Article

    The transcription factor SNAIL represses vitamin D receptor expression and responsiveness in human colon cancer

    Several non-hypercalcemic analogs of 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) show antitumor activity in a subset of cancer patients. High vitamin D receptor (VDR) expression, which is associated with good prognos...

    Héctor G Pálmer, María Jesús Larriba, José Miguel García… in Nature Medicine (2004)