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Identifying Cell Differentiation in Colorectal Cancer
The intestinal epithelium is a rapid self-renewing tissue. Stem cells at the bottom of the crypts first give rise to a proliferative progeny that finally differentiates to a variety of cell types. These termin...
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Article
The transcription factor SNAIL represses vitamin D receptor expression and responsiveness in human colon cancer
Several non-hypercalcemic analogs of 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) show antitumor activity in a subset of cancer patients. High vitamin D receptor (VDR) expression, which is associated with good prognos...