12 Result(s)
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Machteld N. Hylkema
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Article
A Targeted Lipidomic Reveals CYP450-Derived Oxylipin Linked to the Inflammatory Response by Polycyclic Aromatic Hydrocarbon Exposure in Children
Polycyclic aromatic hydrocarbon (PAH) exposure is a cause of chronic inflammation. The effect of PAHs on bioactive lipid mediators involved in the inflammatory process remains largely unknown. This study measu...
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Article
Ubiquitin carboxyl-terminal hydrolase isozyme L1/UCHL1 suppresses epithelial–mesenchymal transition and is under-expressed in cadmium-transformed human bronchial epithelial cells
Cadmium (Cd), a highly toxic heavy metal, is widespreadly distributed in the environment. Chronic exposure to Cd is associated with the development of several diseases including cancers. Over the decade, many ...
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Article
Open AccessDual role of YM1+ M2 macrophages in allergic lung inflammation
Alternatively activated (M2 or YM1+) macrophages have been associated with the development of asthma but their contribution to disease initiation and progression remains unclear. To assess the therapeutic pote...
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Article
Open AccessOld dilemma: asthma with irreversible airway obstruction or COPD
Older asthmatic patients may develop fixed airway obstruction and clinical signs of chronic obstructive pulmonary disease (COPD). We investigated the added value of pathological evaluation of bronchial biopsie...
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Article
Open AccessInter- and transgenerational epigenetic inheritance: evidence in asthma and COPD?
Evidence is now emerging that early life environment can have lifelong effects on metabolic, cardiovascular, and pulmonary function in offspring, a concept also known as fetal or developmental programming. In ...
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Article
Open AccessAtopy is a risk factor for respiratory symptoms in COPD patients: results from the EUROSCOP study
The pathogenesis of COPD is complex and remains poorly understood. The European Respiratory Society Study on Chronic Obstructive Pulmonary Disease (EUROSCOP) investigated long-term effects of budesonide; 18% o...
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Article
Open AccessInduction of autoantibodies against lung matrix proteins and smoke-induced inflammation in mice
Smoking is the major etiologic factor in COPD, yet the exact underlying pathogenetic mechanisms have not been elucidated. Since a few years, there is mounting evidence that a specific immune response, partly p...
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Article
Open AccessCan AMP induce sputum eosinophils, even in subjects with complete asthma remission?
The definition of "clinical asthma remission" is based on absence of symptoms and use of medication. However, in the majority of these subjects airway inflammation is still present when measured. In the present s...
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Article
Open AccessIncreased levels of (class switched) memory B cells in peripheral blood of current smokers
There is increasing evidence that a specific immune response contributes to the pathogenesis of COPD. B-cell follicles are present in lung tissue and increased anti-elastin titers have been found in plasma of ...
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Article
Open AccessHeme oxygenase-1 prevents smoke induced B-cell infiltrates: a role for regulatory T cells?
Smoking is the most important cause for the development of COPD. Since not all smokers develop COPD, it is obvious that other factors must be involved in disease development. We hypothesize that heme oxygenase...
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Article
Role of Adenosine Receptors in the Treatment of Asthma and Chronic Obstructive Pulmonary Disease
Adenosine is a naturally occurring purine nucleoside with a ubiquitous presence in human tissue, where it plays a key role in many biological processes such as energy generation and protein metabolism. It has ...
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Article
Open AccessAcute effects of cigarette smoking on inflammation in healthy intermittent smokers
Chronic smoking is the main risk factor for chronic obstructive pulmonary disease. Knowledge on the response to the initial smoke exposures might enhance the understanding of changes due to chronic smoking, si...
