16 Result(s)
within
Susanne Krauss-Etschmann
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Article
Open AccessThe microbial composition of larval airways from Drosophila melanogaster differ between specimens from laboratory and natural habitats
The fruit fly Drosophila melanogaster lives in natural habitats and has also long been used as a model organism in biological research. In this study, we used a molecular barcoding approach to analyse the airways...
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Open AccessOffspring born to influenza A virus infected pregnant mice have increased susceptibility to viral and bacterial infections in early life
Influenza during pregnancy can affect the health of offspring in later life, among which neurocognitive disorders are among the best described. Here, we investigate whether maternal influenza infection has adv...
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Open AccessPreconceptional smoking alters spermatozoal miRNAs of murine fathers and affects offspring’s body weight
Active smoking has been reported among 7% of teenagers worldwide, with ages ranging from 13 to 15 years. An epidemiological study suggested that preconceptional paternal smoking is associated with adolescent o...
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Open AccessSex dependent effect of maternal e-nicotine on F1 Drosophila development and airways
E-cigarettes are heavily advertised as healthier alternative to common tobacco cigarettes, leading more and more women to switch from regular cigarettes to ENDS (electronic nicotine delivery system) during pre...
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Open AccessEarly life determinants induce sustainable changes in the gut microbiome of six-year-old children
While the association between early life determinants and the development of the gut microbiome composition in infancy has been widely investigated, a potential persistent influence of early life determinants ...
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Open AccessIntrauterine smoke exposure deregulates lung function, pulmonary transcriptomes, and in particular insulin-like growth factor (IGF)-1 in a sex-specific manner
Prenatal exposure to tobacco smoke is a significant risk-factor for airway disease development. Furthermore, the high prevalence of pregnant smoking women requires the establishment of strategies for offspring...
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Development of a Stable Lung Microbiome in Healthy Neonatal Mice
The lower respiratory tract has been previously considered sterile in a healthy state, but advances in culture-independent techniques for microbial identification and characterization have revealed that the lu...
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Open AccessPulmonary microRNA profiles identify involvement of Creb1 and Sec14l3 in bronchial epithelial changes in allergic asthma
Asthma is highly prevalent, but current therapies cannot influence the chronic course of the disease. It is thus important to understand underlying early molecular events. In this study, we aimed to use microR...
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Open AccessValidated prediction of pro-invasive growth factors using a transcriptome-wide invasion signature derived from a complex 3D invasion assay
The invasion of activated fibroblasts represents a key pathomechanism in fibrotic diseases, carcinogenesis and metastasis. Invading fibroblasts contribute to fibrotic extracellular matrix (ECM) formation and t...
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Open AccessInter- and transgenerational epigenetic inheritance: evidence in asthma and COPD?
Evidence is now emerging that early life environment can have lifelong effects on metabolic, cardiovascular, and pulmonary function in offspring, a concept also known as fetal or developmental programming. In ...
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Die Bedeutung des humanen Mikrobioms für die menschliche Gesundheit
The human microbiome drives important functional traits like transformation of food, generation of vitamins, stimulation of the immune system and defense from pathogens, which can be considered as the key for ...
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Open AccessRelationship between genome and epigenome - challenges and requirements for future research
Understanding the links between genetic, epigenetic and non-genetic factors throughout the lifespan and across generations and their role in disease susceptibility and disease progression offer entirely new av...
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MicroRNA Methodology: Advances in miRNA Technologies
There is an emerging trend in microRNA research and thus substantial progress in microRNA technologies. In this chapter we provide insights into the main microRNA specific methodologies and critical steps of m...
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Cleavage of CXCR1 on neutrophils disables bacterial killing in cystic fibrosis lung disease
Interleukin-8 (IL-8) activates neutrophils via the chemokine receptors CXCR1 and CXCR2. However, the airways of individuals with cystic fibrosis are frequently colonized by bacterial pathogens, despite the pre...
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Open AccessPre-natal and post-natal exposure to respiratory infection and atopic diseases development: a historical cohort study
According to the hygiene hypothesis, infections in early life protect from allergic diseases. However, in earlier studies surrogate measures of infection rather than clinical infections were associated with de...
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Open AccessA role for MCP-1/CCR2 in interstitial lung disease in children
Interstitial lung diseases (ILD) are chronic inflammatory disorders leading to pulmonary fibrosis. Monocyte chemotactic protein 1 (MCP-1) promotes collagen synthesis and deletion of the MCP-1 receptor CCR2 pro...
