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Article
Open AccessWHO grade I meningiomas that show regrowth after gamma knife radiosurgery often show 1p36 loss
WHO grade I meningiomas occasionally show regrowth after radiosurgical treatment, which cannot be predicted by clinical features. There is increasing evidence that certain biomarkers are associated with regrow...
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Article
Open AccessPrognostic relevance of mutations and copy number alterations assessed with targeted next generation sequencing in IDH mutant grade II glioma
At current prognostication of low grade glioma remains suboptimal and might be improved with additional markers. These may guide treatment decisions, in particular on early adjuvant therapy versus wait and see...
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Article
Open AccessOld dilemma: asthma with irreversible airway obstruction or COPD
Older asthmatic patients may develop fixed airway obstruction and clinical signs of chronic obstructive pulmonary disease (COPD). We investigated the added value of pathological evaluation of bronchial biopsie...
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Article
Open AccessSpatial and temporal evolution of distal 10q deletion, a prognostically unfavorable event in diffuse low-grade gliomas
The disease course of patients with diffuse low-grade glioma is notoriously unpredictable. Temporal and spatially distinct samples may provide insight into the evolution of clinically relevant copy number aber...
