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  1. No Access

    Chapter

    Oxygen Dependency of Cerebral CuA Redox State During Increased Oxygen Consumption Produced by Infusion of a Mitochondrial Uncoupler in Newborn Piglets

    The mitochondrial uncoupler 2, 4-dinitrophenol (DNP) is a membrane soluble weak acid that is capable of transporting protons across the proton-impermeable inner mitochondrial membrane (Skulachev, 1998). This r...

    R. Springett, J. Newman, D. T. Delpy, M. Cope in Oxygen Transport to Tissue XXI (1999)

  2. No Access

    Article

    Electrical and Microwave Properties of Mn Implanted (Ba,Sr)TiO3 Thin Films

    We have used ion implantation to dope polycrystalline BaxSr(1-x)TiO3 (BST) thin films with Mn. Dopant concentrations were varied in the range of 0.1 at % to 2 at % Mn. X-ray diffraction and TEM studies show that ...

    J. D. Baniecki, R. B. Laibowitz, T. M. Shaw… in MRS Online Proceedings Library (1997)

  3. No Access

    Chapter

    An Analytical Method for Determining Cerebrovascular Transit Time Using Near Infrared Spectroscopy

    The measurement of cerebral blood flow (CBF) using near infrared spectroscopy (NIRS) is already well described (Edwards et al, 1988, Elwell et al, 1994, Owen-Reece et al., 1996). The technique requires the use...

    C. E. Elwell, M. Cope, D. T. Delpy in Oxygen Transport to Tissue XIX (1997)

  4. No Access

    Chapter

    Measurement of Cytochrome Oxidase Redox State by Near Infrared Spectroscopy

    Although near infrared spectroscopy (NIRS) is primarily used to probe changes in oxyhaemoglobin (HbO2) and deoxyhaemoglobin (dHb) concentrations, it has long been realised that there is a significant oxygen-conce...

    C. E. Cooper, M. Cope, V. Quaresima… in Optical Imaging of Brain Function and Meta… (1997)

  5. Article

    The Noninvasive Measurement of Absolute Cerebral Deoxyhemoglobin Concentration and Mean Optical Path Length in the Neonatal Brain by Second Derivative Near Infrared Spectroscopy

    We have used second differential near infrared spectroscopy of water to determine the mean optical path length of the neonatal brain. By obtaining the ratio of the second differential features of deoxyhemoglob...

    C E Cooper, C E Elwell, J H Meek, S J Matcher, J S Wyatt, M Cope… in Pediatric Research (1996)

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    Article

    Synthesis and assembly of flagellar surface antigens during zoosporogenesis inPhytophthora cinnamomi

    Cryomicrotomy and immunofluorescence microscopy employing three different categories of monoclonal antibody (MAb) that label antigens on the surface of one or both flagella ofPhytophthora dnnamomi have been used ...

    M. Cope, A. R. Hardham in Protoplasma (1994)

  7. No Access

    Article

    Cell surface antigens ofPhytophthora spores: biological and taxonomic characterization

    The oomycetes are a class of protists that produce biflagellate asexual zoospores. Members of the oomycetes have close phylogenetic affinities with the chromophyte algae and are widely divergent from the highe...

    A. R. Hardham, D. M. Cahill, M. Cope, B. K. Gabor, F. Gubler, G. J. Hyde in Protoplasma (1994)

  8. No Access

    Chapter

    An Automated System for the Measurement of the Response of Cerebral Blood Volume and Cerebral Blood Flow to Changes in Arterial Carbon Dioxide Tension Using Near Infrared Spectroscopy

    Since it was first described by Jobsis in 1977, near infrared spectroscopy (NIRS) has become widely used as a non invasive technique for monitoring the blood and tissue oxygenation of intact organs and to date...

    C. E. Elwell, M. Cope, D. Kirkby, H. Owen-Reece… in Oxygen Transport to Tissue XVI (1994)

  9. No Access

    Chapter

    Measurement of Changes in Cerebral Haemodynamics During Inspiration and Expiration Using Near Infrared Spectroscopy

    Near infrared spectroscopy (NIRS) has been employed over the last decade to monitor the changes in tissue oxygenation of intact organs (Jobsis 1977, Brazy et al. 1985, 1986, Ferrari et al. 1986a, 1986b, Hampso...

    C. E. Elwell, H. Owen-Reece, M. Cope, A. D. Edwards… in Oxygen Transport to Tissue XV (1994)

  10. No Access

    Chapter and Conference Paper

    Modelling photochemical pollution using parallel and distributed computing platforms

    Scientists are increasingly turning to numerical simulation in order to investigate and model complex environmental systems. Numerical simulation has enormous advantages over laboratory or field experimentatio...

    D. Abramson, M. Cope, R. McKenzie in PARLE'94 Parallel Architectures and Languages Europe (1994)

  11. No Access

    Chapter

    Cell surface antigens of Phytophthora spores: biological and taxonomic characterization

    The oomycetes are a class of protists that produce biflagellate asexual zoospores. Members of the oomycetes have close phylogenetic affinities with the chromophyte algae and are widely divergent from the highe...

    A. R. Hardham, D. M. Cahill, M. Cope, B. K. Gabor, F. Gubler… in The Protistan Cell Surface (1994)

  12. Article

    Effects of N-ω-Nitro-L-Arginine Methyl Ester on the Cerebral Circulation of Newborn Piglets Quantified In Vivo by Near-Infrared Spectroscopy

    ABSTRACT: The effects of N--nitro-L-arginine methyl ester (L-NAME) on basal cerebral vascular tone, the vasodilatory effects of acetylcholine (ACh), and the cerebrovascular response to alterations in arterial ...

    Y Takei, A D Edwards, A Lorek, D M Peebles, A Belai, M Cope… in Pediatric Research (1993)

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  13. Article

    Effect of Indomethacin on Cerebral Oxidized Cytochrome Oxidase in Preterm Infants

    ABSTRACT: To determine the effect of i.v. indomethacin on cerebral intracellular oxygenation, as judged by changes in the concentration of oxidized cytochrome oxidase, studies were performed using near-infrare...

    D C Mccormick, A D Edwards, G C Brown, J S Wyatt, A Potter, M Cope… in Pediatric Research (1993)

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  14. No Access

    Chapter

    Wavelength Dependence of the Differential Pathlength Factor and the Log Slope in Time-Resolved Tissue Spectroscopy

    The monitoring of tissue oxygenation by the technique of near infrared spectroscopy (NIRS) was first described by Jöbsis in 1977 (Jöbsis, 1977). The technique relies upon the relative transparency of tissue to...

    M. Essenpreis, M. Cope, C. E. Elwell… in Optical Imaging of Brain Function and Meta… (1993)

  15. No Access

    Chapter

    Measurement of Adult Cerebral Haemodynamics Using Near Infrared Spectroscopy

    Near infrared spectroscopy (NIRS) is a non invasive, portable, safe technique for monitoring cerebral oxygenation and haemodynamics. Since it does not involve the use of ionising radiation it may be used repea...

    C. E. Elwell M. Phil., H. Owen-Reece… in Monitoring of Cerebral Blood Flow and Meta… (1993)

  16. Article

    EFFECT OF FREQUENCY OF UTERINE CONTRACTIONS ON HUMAN FETAL CEREBRAL OXYGENATION MEASURED BY NEAR INFRARED SPECTROSCOPY (NIRS)

    The purpose of this investigation was to study the effect of uterine contraction frequency on the cerebral concentrations of oxyhaecmoglobin (HbO2) and deoxyliacmoglobin (Hb) measured by NIRS. Two optical fibr...

    D M Peebles, A D Edwards, J S Wyalt, A P Bishop, M Cope, D T Delpy… in Pediatric Research (1992)

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  17. Article

    Cerebral Hemodynamic Effects of Treatment with Modified Natural Surfactant Investigated by Near Infrared Spectroscopy

    The purpose of this study was to investigate the effects on cerebral hemodynamics of administering modified natural surfactant (Curosurf, 200 mg · kg-1) to infants requiring mechanical ventilation for hyaline mem...

    A D Edwards, D C McCormick, S C Roth, C E Elwell, D M Peebles, M Cope… in Pediatric Research (1992)

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  18. No Access

    Chapter

    Oxygen Consumption of Human Skeletal Muscle by Near Infrared Spectroscopy during Tourniquet-Induced Ischemia in Maximal Voluntary Contraction

    Among tissues, skeletal muscle shows the highest variability in energy turnover from the resting state through to maximal activity so that muscle is particularly suitable for investigation of metabolic regulat...

    R. A. De Blasi, M. Cope, M. Ferrari in Oxygen Transport to Tissue XIV (1992)

  19. No Access

    Chapter

    Experimentally Measured Optical Pathlengths for the Adult Head, Calf and Forearm and the Head of the Newborn Infant as a Function of Inter Optode Spacing

    The technique of near infrared spectroscopy (NIRS) is being increasingly used in clinical measurements of blood and tissue oxygenation (Wyatt et al 1986, Edwards et al 1990). and there are now several commerci...

    P. van der Zee, M. Cope, S. R. Arridge, M. Essenpreis… in Oxygen Transport to Tissue XIII (1992)

  20. No Access

    Chapter

    Measurement of Cerebral Blood Flow in Adult Humans Using Near Infrared Spectroscopy — Methodology and Possible Errors

    The principle of near infrared spectroscopy (NIRS) was first clearly defined by Jobsis in 1977, and recent technical and methodological advances have made it possible to use NIRS to make non-invasive, quantita...

    C. E. Elwell, M. Cope, A. D. Edwards, J. S. Wyatt… in Oxygen Transport to Tissue XIV (1992)

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