Abstract
Since it was first described by Jobsis in 1977, near infrared spectroscopy (NIRS) has become widely used as a non invasive technique for monitoring the blood and tissue oxygenation of intact organs and to date has been primarily applied to measurements of cerebral oxygenation and haemodynamics (Brazy et al., 1985, 1986, Ferrari et al., 1986, Hampson et al., 1990). Methods have been developed to make discrete absolute measurements of cerebral blood volume (CBV) (Wyatt et al., 1990) and cerebral blood flow (CBF) (Edwards et al., 1988) by inducing a small change in cerebral oxyhaemoglobin concentration and have largely been applied to neonates (Edwards et al., 1990, Skov et al., 1991). More recently these methods of quantifying cerebral haemodynamics have been applied to adults (Elwell et al., 1992).
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Elwell, C.E. et al. (1994). An Automated System for the Measurement of the Response of Cerebral Blood Volume and Cerebral Blood Flow to Changes in Arterial Carbon Dioxide Tension Using Near Infrared Spectroscopy. In: Hogan, M.C., Mathieu-Costello, O., Poole, D.C., Wagner, P.D. (eds) Oxygen Transport to Tissue XVI. Advances in Experimental Medicine and Biology, vol 361. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1875-4_19
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DOI: https://doi.org/10.1007/978-1-4615-1875-4_19
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