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Article
RCCD1 promotes breast carcinogenesis through regulating hypoxia-associated mitochondrial homeostasis
Regulator of chromosome condensation domain-containing protein 1 (RCCD1), previously reported as a partner of histone H3K36 demethylase KDM8 involved in chromosome segregation, has been identified as a potenti...
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Article
Open AccessGlobal genetic diversity, introgression, and evolutionary adaptation of indicine cattle revealed by whole genome sequencing
Indicine cattle, also referred to as zebu (Bos taurus indicus), play a central role in pastoral communities across a wide range of agro-ecosystems, from extremely hot semiarid regions to hot humid tropical region...
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Article
Open AccessRapid Mycobacterium abscessus antimicrobial susceptibility testing based on antibiotic treatment response map** via Raman Microspectroscopy
Antimicrobial susceptibility tests (ASTs) are pivotal tools for detecting and combating infections caused by multidrug-resistant rapidly growing mycobacteria (RGM) but are time-consuming and labor-intensive.
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Article
Open AccessNFIB facilitates replication licensing by acting as a genome organizer
The chromatin-based rule governing the selection and activation of replication origins in metazoans remains to be investigated. Here we report that NFIB, a member of Nuclear Factor I (NFI) family that was init...
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Article
Genome-wide association study reveals that the IBSP locus affects ear size in cattle
Ear size is a classical model for hot climate adaptation following the evolution, but the genetic basis of the traits associated with ear size remains to be elucidated. Here, we performed a genome-wide associa...
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Article
Open AccessRootstock–scion interaction affects Malus transcriptome profiles in response to cadmium
Apple production is threatened by cadmium contamination in orchards. Cd accumulation and tolerance in grafted Malus plants is affected by rootstock, scion, and their interaction. This dataset is part of an experi...
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Article
Mild and metal-free Birch-type hydrogenation of (hetero)arenes with boron carbonitride in water
The direct reduction of inert planar arenes and heteroarenes with visible light remains rarely explored, as the energy of one visible-light photon is unable to overcome the stabilization of aromatics. Here we ...
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Article
Open AccessThe existence of a nonclassical TCA cycle in the nucleus that wires the metabolic-epigenetic circuitry
The scope and variety of the metabolic intermediates from the mitochondrial tricarboxylic acid (TCA) cycle that are engaged in epigenetic regulation of the chromatin function in the nucleus raise an outstandin...
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Article
Altered chromatin states drive cryptic transcription in aging mammalian stem cells
A repressive chromatin state featuring trimethylated lysine 36 on histone H3 (H3K36me3) and DNA methylation suppresses cryptic transcription in embryonic stem cells. Cryptic transcription is elevated with age ...
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Article
The IRENA lncRNA converts chemotherapy-polarized tumor-suppressing macrophages to tumor-promoting phenotypes in breast cancer
Although chemotherapy can stimulate antitumor immunity by inducing interferon (IFN) response, the functional role of tumor-associated macrophages in this scenario remains unclear. Here, we found that IFN-activ...
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Article
Open AccessInactivating histone deacetylase HDA promotes longevity by mobilizing trehalose metabolism
Histone acetylations are important epigenetic markers for transcriptional activation in response to metabolic changes and various stresses. Using the high-throughput SEquencing-Based Yeast replicative Lifespan...
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Article
Tracking break-induced replication shows that it stalls at roadblocks
Break-induced replication (BIR) repairs one-ended double-strand breaks in DNA similar to those formed by replication collapse or telomere erosion, and it has been implicated in the initiation of genome instabi...
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Article
Open AccessBroadband bifunctional Luneburg–Fisheye lens based on anisotropic metasurface
Luneburg lenses and Maxwell fisheye lenses possess distinct properties of focusing, well beyond conventional lenses made of uniform materials. In this paper, a planar broadband bifunctional Luneburg-fisheye le...
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Article
Open AccessSIRT7 slows down stem cell aging by preserving heterochromatin: a perspective on the new discovery
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Article
Imbalance of the reciprocally inhibitory loop between the ubiquitin-specific protease USP43 and EGFR/PI3K/AKT drives breast carcinogenesis
Hyperactivation of EGFR/PI3K/AKT is a prominent feature of various human cancers. Thus, understanding how this molecular cascade is balanced is of great importance. We report here that the ubiquitin-specific p...
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Article
Open AccessJMJD6 promotes melanoma carcinogenesis through regulation of the alternative splicing of PAK1, a key MAPK signaling component
Melanoma, originated from melanocytes located on the basal membrane of the epithelial tissue, is the most aggressive form of skin cancer that accounts for 75% of skin cancer-related death. Although it is belie...
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Article
Open AccessZNF516 suppresses EGFR by targeting the CtBP/LSD1/CoREST complex to chromatin
EGFR is required for animal development, and dysregulation of EGFR is critically implicated in malignant transformation. However, the molecular mechanism underlying the regulation of EGFR expression remains po...
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Article
GWAS analysis of QTL for enteric septicemia of catfish and their involved genes suggest evolutionary conservation of a molecular mechanism of disease resistance
Disease problems cause major economic losses for the aquaculture industries. In catfish, enteric septicemia of catfish (ESC), caused by the bacterial pathogen Edwardsiella ictaluri, is the leading disease problem...
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Article
Nucleation of DNA repair factors by FOXA1 links DNA demethylation to transcriptional pioneering
Yongfeng Shang and colleagues report that the pioneering factor FOXA1 associates with DNA repair complexes and regulates DNA demethylation at its genomic targets in a DNA polymerase β–dependent manner. They sh...
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Article
Open AccessSIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability
Although SIRT7 is a member of sirtuin family proteins that are described as NAD+-dependent class III histone deacetylases, the intrinsic enzymatic activity of this sirtuin protein remains to be investigated and t...
